Date published: 2026-4-29

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3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole (CAS 887144-97-0)

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Alternate Names:
1,3-Dihydro-3,3-dimethyl-1-(trifluoromethyl)-1,2-benziodoxole; Tognis Reagent
Application:
3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole is used in trifluormethylation of a variety of compounds
CAS Number:
887144-97-0
Purity:
≥95%
Molecular Weight:
330.09
Molecular Formula:
C10H10F3IO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole is used in trifluormethylation of a variety of compounds. Used as a control agent for electron-transfer reactions. Used in the synthesis of various polymers and materials. Addtionally, it is used as a starting material for the synthesis of various heterocyclic compounds, such as quinolines, pyridines, and thiophenes.


3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole (CAS 887144-97-0) References

  1. 2'-SCF3 uridine-a powerful label for probing structure and function of RNA by 19F NMR spectroscopy.  |  Fauster, K., et al. 2012. Angew Chem Int Ed Engl. 51: 13080-4. PMID: 23161779
  2. Copper-mediated radical trifluoromethylation of unsaturated potassium organotrifluoroborates.  |  Presset, M., et al. 2013. J Org Chem. 78: 12837-43. PMID: 24251623
  3. Expanding the Scope of 2'-SCF3 Modified RNA.  |  Jud, L., et al. 2015. Chemistry. 21: 10400-7. PMID: 26074479
  4. Isolation and Reactivity of Trifluoromethyl Iodonium Salts.  |  Brantley, JN., et al. 2016. ACS Cent Sci. 2: 341-50. PMID: 27280169
  5. Access to a new class of synthetic building blocks via trifluoromethoxylation of pyridines and pyrimidines.  |  Feng, P., et al. 2016. Chem Sci. 7: 424-429. PMID: 27857834
  6. Metal-free, intermolecular carbopyridylation of alkenes via visible-light-induced reductive radical coupling.  |  Chen, D., et al. 2018. Chem Sci. 9: 9012-9017. PMID: 30647893
  7. Hypervalent Iodine Compounds as Versatile Reagents for Extremely Efficient and Reversible Patterning of Graphene with Nanoscale Precision.  |  Bao, L., et al. 2021. Adv Mater. 33: e2101653. PMID: 34173280

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3,3-Dimethyl-1-(trifluoromethyl)-1,2-benziodoxole, 250 mg

sc-231940
250 mg
$87.00