Molecular structure of 3,3,5-Trimethylcyclohexyl Salicylate, CAS Number: 118-56-9
3,3,5-Trimethylcyclohexyl Salicylate (CAS 118-56-9)
Alternate Names:
2-Hydroxybenzoic Acid 3,3,5-Trimethylcyclohexyl Ester; Salicylic Acid 3,3,5-Trimethylcyclohexyl Ester
CAS Number:
118-56-9
Molecular Weight:
262.35
Molecular Formula:
C16H22O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
3,3,5-Trimethylcyclohexyl Salicylate, classified as a salicylate, is an organic compound resulting from the esterification of salicylic acid and 3,3,5-trimethylcyclohexanol, a derivative of cyclohexanol. The compound 3,3,5-trimethylcyclohexylsalicylate appears as a viscous liquid or light yellow to slightly tan oil. It is categorized as a benzoate ester and belongs to the phenol family. It is a derivative of salicylic acid. 3,3,5-Trimethylcyclohexyl Salicylate, a UV filter, provides protection against the harmful impact of UVB (280-315 nm) and UVA II (315-340 nm) radiations on the skin. Notably, 3,3,5-Trimethylcyclohexyl Salicylate specifically absorbs short-wave UVB rays.
3,3,5-Trimethylcyclohexyl Salicylate (CAS 118-56-9) References
- Sensitive determination of salicylate and benzophenone type UV filters in water samples using solid-phase microextraction, derivatization and gas chromatography tandem mass spectrometry. | Negreira, N., et al. 2009. Anal Chim Acta. 638: 36-44. PMID: 19298877
- Determination of selected UV filters in indoor dust by matrix solid-phase dispersion and gas chromatography-tandem mass spectrometry. | Negreira, N., et al. 2009. J Chromatogr A. 1216: 5895-902. PMID: 19539293
- Simultaneous determination of the UV-filters benzyl salicylate, phenyl salicylate, octyl salicylate, homosalate, 3-(4-methylbenzylidene) camphor and 3-benzylidene camphor in human placental tissue by LC-MS/MS. Assessment of their in vitro endocrine activity. | Jiménez-Díaz, I., et al. 2013. J Chromatogr B Analyt Technol Biomed Life Sci. 936: 80-7. PMID: 24004914
- Percutaneous absorption, disposition, and exposure assessment of homosalate, a UV filtering agent, in rats. | Kim, TH., et al. 2014. J Toxicol Environ Health A. 77: 202-13. PMID: 24555679
- Evaluation of the endocrine-disrupting effects of homosalate (HMS) and 2-ethylhexyl 4-dimethylaminobenzoate (OD-PABA) in rat pups during the prenatal, lactation, and early postnatal periods. | Erol, M., et al. 2017. Toxicol Ind Health. 33: 775-791. PMID: 28879804
- Homosalate aggravates the invasion of human trophoblast cells as well as regulates intracellular signaling pathways including PI3K/AKT and MAPK pathways. | Yang, C., et al. 2018. Environ Pollut. 243: 1263-1273. PMID: 30267922
- Assessment of the cytotoxicity and genotoxicity of homosalate in MCF-7. | Yazar, S. and Kara Ertekin, S. 2020. J Cosmet Dermatol. 19: 246-252. PMID: 31021040
- Effect of Sunscreen Application on Plasma Concentration of Sunscreen Active Ingredients: A Randomized Clinical Trial. | Matta, MK., et al. 2020. JAMA. 323: 256-267. PMID: 31961417
- Insights into the photoprotection mechanism of the UV filter homosalate. | Holt, EL., et al. 2020. Phys Chem Chem Phys. 22: 15509-15519. PMID: 32602867
- Determination of urinary metabolites of the UV filter homosalate by online-SPE-LC-MS/MS. | Ebert, KE., et al. 2021. Anal Chim Acta. 1176: 338754. PMID: 34399889
- Photodegradation of Bexarotene and Its Implication for Cytotoxicity. | Kryczyk-Poprawa, A., et al. 2021. Pharmaceutics. 13: PMID: 34452181
- Homosalate boosts the release of tumour-derived extracellular vesicles with protection against anchorage-loss property. | Grisard, E., et al. 2022. J Extracell Vesicles. 11: e12242. PMID: 35790086
- Photostability of the deprotonated forms of the UV filters homosalate and octyl salicylate: molecular dissociation versus electron detachment following UV excitation. | Wong, NGK., et al. 2022. Phys Chem Chem Phys. 24: 17068-17076. PMID: 35791920
- Diastereoselective metabolism of homomenthyl salicylate (homosalate): Identification of relevant human exposure biomarkers. | Ebert, KE., et al. 2022. Environ Int. 170: 107637. PMID: 36423396
- Dispersive liquid-liquid microextraction and Monte Carlo simulation of margin of safety for octocrylene, EHMC, 2ES, and homosalate in sunscreens. | Lukić, J., et al. 2023. Biomed Chromatogr. 37: e5590. PMID: 36709999
Inhibitor of:
Ran BP-4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3,3,5-Trimethylcyclohexyl Salicylate, 25 g | sc-477282 | 25 g | $45.00 | |||
3,3,5-Trimethylcyclohexyl Salicylate, 100 g | sc-477282A | 100 g | $171.00 |