Date published: 2026-1-20

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3,3,3-Trifluoropropionyl chloride (CAS 41463-83-6)

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CAS Number:
41463-83-6
Purity:
97%
Molecular Weight:
146.50
Molecular Formula:
C3H2ClF3O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3,3,3-Trifluoropropionyl chloride is a chemical compound belonging to the class of acyl chlorides. It consists of a trifluoromethyl group attached to a propionyl group, with a chlorine atom replacing one of the hydrogen atoms in the acyl group. This compound is primarily used as a reagent in organic synthesis, particularly in the introduction of the trifluoromethyl group into various organic molecules. The trifluoropropionyl chloride serves as a source of the trifluoromethyl moiety in reactions.


3,3,3-Trifluoropropionyl chloride (CAS 41463-83-6) References

  1. Studies on Ca2+ channel antagonists. A 2-diazo-3,3,3-trifluoropropionamide derivative related to verapamil as a potential photoaffinity probe.  |  Theodore, LJ., et al. 1990. J Med Chem. 33: 873-7. PMID: 2153831
  2. Chemistry of ecteinascidins. Part 4: preparation of 2'-N-acyl ecteinascidin 770 derivatives with improved cytotoxicity profiles.  |  Tsujimoto, M., et al. 2013. Chem Pharm Bull (Tokyo). 61: 1052-64. PMID: 24088697
  3. Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer.  |  Tokay, E., et al. 2020. Eur J Med Chem. 187: 111937. PMID: 31841727
  4. Suicide inactivation of fructose-1,6-bisphosphate aldolase.  |  Magnien, A., et al. 1984. Biochemistry. 23: 6858-62. PMID: 6529585
  5. POCl3-mediated synthesis of hydrolysis-prone 2-trifluoroethylbenzimidazoles  |  Kausik K. Nanda, B. Wesley Trotter. 2008. Tetrahedron Letters. 49: 5332-5335.
  6. Calculated and experimental rotational spectra of 3,3,3-trifluoro- and 2,2,3,3-tetrafluoropropionyl chloride  |  W.C. Bailey a, R.A. Powoski b 1, S.A. Cooke c. 2012. Journal of Molecular Spectroscopy. 273: 1-5.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3,3,3-Trifluoropropionyl chloride, 5 g

sc-261130
5 g
$338.00

3,3,3-Trifluoropropionyl chloride, 10 g

sc-261130A
10 g
$544.00