Date published: 2025-10-18

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3,3,3-Trifluoro-DL-alanine (CAS 17463-43-3)

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CAS Number:
17463-43-3
Molecular Weight:
143.06
Molecular Formula:
C3H4F3NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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3,3,3-Trifluoro-DL-alanine (TFA) is an amino acid widely used in scientific research applications, including biochemical, physiological, and laboratory experiments. It is able to form strong hydrogen bonds with other molecules due to its trifluoromethyl group. It is used in the synthesis of peptides, proteins, and other biological molecules. Additionally, it is employed in the study of enzyme kinetics, biochemical pathways, metabolic pathways, protein folding and structure, and protein-protein interactions. 3,3,3-Trifluoro-DL-alanine has also been found to affect the activity of ion channels in cells and neurotransmitters.


3,3,3-Trifluoro-DL-alanine (CAS 17463-43-3) References

  1. Studies on the reaction mechanism of Rhodotorula gracilis D-amino-acid oxidase. Role of the highly conserved Tyr-223 on substrate binding and catalysis.  |  Harris, CM., et al. 1999. J Biol Chem. 274: 36233-40. PMID: 10593911
  2. Glycine-dependent activation of NMDA receptors.  |  Cummings, KA. and Popescu, GK. 2015. J Gen Physiol. 145: 513-27. PMID: 25964432
  3. The broad amine scope of pantothenate synthetase enables the synthesis of pharmaceutically relevant amides.  |  Abidin, MZ., et al. 2021. Org Biomol Chem. 19: 4515-4519. PMID: 33913984

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

3,3,3-Trifluoro-DL-alanine, 100 mg

sc-226198
100 mg
$186.00