Molecular structure of 3-(2,5-dimethyl-1H-pyrrol-1-yl)thiophene-2-carboxylic acid, CAS Number: 477888-48-5
3-(2,5-dimethyl-1H-pyrrol-1-yl)thiophene-2-carboxylic acid (CAS 477888-48-5)
See product citations (4)
CAS Number:
477888-48-5
Molecular Weight:
221.28
Molecular Formula:
C11H11NO2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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3-(2,5-dimethyl-1H-pyrrol-1-yl)thiophene-2-carboxylic acid, also called Pyrrothiogatain, is a novel inhibitor of GATA family proteins. It targets the DNA-binding activity of GATA3 and other members of the GATA family, inhibiting the interaction between GATA3 and SOX4. This significantly suppresses Th2 cell differentiation without impairing Th1 cell differentiation and inhibits the expression and production of Th2 cytokines.
3-(2,5-dimethyl-1H-pyrrol-1-yl)thiophene-2-carboxylic acid (CAS 477888-48-5) References
- The Inhibitory Effect of GlmU Acetyltransferase Inhibitor TPSA on Mycobacterium tuberculosis May Be Affected Due to Its Methylation by Methyltransferase Rv0560c. | Chen, C., et al. 2019. Front Cell Infect Microbiol. 9: 251. PMID: 31380295
- Pyrrothiogatain acts as an inhibitor of GATA family proteins and inhibits Th2 cell differentiation in vitro. | Nomura, S., et al. 2019. Sci Rep. 9: 17335. PMID: 31758034
- Targeting DNA binding proteins for cancer therapy. | Shiroma, Y., et al. 2020. Cancer Sci. 111: 1058-1064. PMID: 32073717
- SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway. | Bortolotti, D., et al. 2020. Cells. 9: PMID: 32859121
- Noncoding genetic variation in GATA3 increases acute lymphoblastic leukemia risk through local and global changes in chromatin conformation. | Yang, H., et al. 2022. Nat Genet. 54: 170-179. PMID: 35115686
- Genome-wide CRISPR screens identify GATA6 as a proviral host factor for SARS-CoV-2 via modulation of ACE2. | Israeli, M., et al. 2022. Nat Commun. 13: 2237. PMID: 35469023
- GATA3 as an immunomodulator in obesity-related metabolic dysfunction associated with fatty liver disease, insulin resistance, and type 2 diabetes. | El-Arabey, AA. and Abdalla, M. 2022. Chem Biol Interact. 366: 110141. PMID: 36058260
- Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity. | Kalim, KW., et al. 2022. J Immunother Cancer. 10: PMID: 36427906
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-(2,5-dimethyl-1H-pyrrol-1-yl)thiophene-2-carboxylic acid, 250 mg | sc-352288 | 250 mg | $469.00 | |||
3-(2,5-dimethyl-1H-pyrrol-1-yl)thiophene-2-carboxylic acid, 1 g | sc-352288A | 1 g | $938.00 |