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8-CPT-cAMP is an efficient activator of cGKI (cyclic-GMP-dependent protein kinase) and PKA (cAMP-PK). Additionally, 8-CPT-cAMP is a robust inhibitor of PDE (cyclic GMP-specific phosphodiesterase) (IC50= 0.9 muM). cGMP-inhibited phosphodiesterase and Ca2+/calmodulin-dependent phosphodiesterase have been reported to hydrolyze 8-CPT-cAMP. 8-CPT-cAMP has been used in studies to analyze the signal-transduction pathways initiated by cAMP-PK and cGMP-PK. Research indicates that 8-CPT-cAMP can inhibit thrombin-induced phosphorylation mediated by protein kinase C and myosin light chain kinase.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[2-(4-Bromo-2-fluorophenoxy)phenyl]acrylic acid, 500 mg | sc-310648 | 500 mg | $296.00 | |||
3-[2-(4-Bromo-2-fluorophenoxy)phenyl]acrylic acid, 1 g | sc-310648A | 1 g | $400.00 |