![3-[1,2,4]Triazol-1-yl-adamantane-1-carboxylic acid (CAS 418805-51-3) - chemical structure image](https://media.scbt.com/product/3-1-2-4triazol-1-yl-adamantane-1-carboxylic-acid-418805-51-3-structure_22_69_b_226918.jpg)
![3-[1,2,4]Triazol-1-yl-adamantane-1-carboxylic acid (CAS 418805-51-3) - chemical structure image](https://media.scbt.com/product/3-1-2-4triazol-1-yl-adamantane-1-carboxylic-acid-418805-51-3-structure_22_69_t_226918.jpg "Molecular structure of 3-[1,2,4]Triazol-1-yl-adamantane-1-carboxylic acid, CAS Number: 418805-51-3")
3-[1,2,4]Triazol-1-yl-adamantane-1-carboxylic acid (CAS 418805-51-3)
QUICK LINKS
SB-216763 is a cell-permeable, potent, selective and ATP-competitive inhibitor of GSK-3 (Glycogen Synthase Kinase) with an IC50 value of 34 nM for GSK-3alpha and with similar potency for GSK-3beta. In PC-12 cells, SB-216763 exhibits neuroprotective properties and protects cultured central and peripheral nervous system neurones from cell death. Furthermore, SB-216763 increases the concentration of cytoplasmic beta-catenin through a GSK-3 dependent manner. These inhibitory effects are similar to those of Wnt. It exhibits promising anti-inflammatory properties and acts as an inhibitor of the enzyme cyclooxygenase-2 (COX-2). The compound has proven valuable in studying SB-216763 inhibition′s impact on inflammation, pain, cell proliferation, and apoptosis. Moreover, it has been employed in synthesizing organic compounds and explored for potential use in drug design.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[1,2,4]Triazol-1-yl-adamantane-1-carboxylic acid, 500 mg | sc-310622 | 500 mg | $260.00 |