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FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 is a cell-permeable pyridopyrimidine compound that may act to act as a potent, ATP-competitive, and reversible inhibitor of FGF and VEGF receptors {IC50 = 21.5 nM for Flg (FGFR1)}. It has been used to inhibit PDGFR and c-Src only at much higher concentration (IC50 = 17.6 muM, 19.8 muM, respectively) and exhibits little effect against EGFR, InsR, MEK, and cPKC even at concentrations as high as 50 muM. It has also been shown to inhibit the autophosphorylation of endogenous Flg (FGFR1, IC50
Ordering Information
Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[(Benzo[1,3]dioxol-5-ylmethyl)-amino]-propan-1-ol, 500 mg | sc-310576 | 500 mg | $260.00 |