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KN-62 has demonstrated potent and selective inhibition of Ca2+/calmodulin-dependent protein kinase II (CaMKII Ki=0.9 muM) which causes cells to arrest in the S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 muM of KN-62 blocked CaMKII phosphorylation of III-AC, and inhibited hormone-stimulated Ca2+ oscillations. Additionally, KN-62 is a potent non-competitive antagonist at the P2X7 receptor (IC50 = 15 nM). KN-62 is a cell-permeable compound that selectively inhibits CaM kinase II, an enzyme involved in calcium signaling (IC50 = 500 nM).
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[(4-Chloro-3-methylphenoxy)methyl]-4-methoxybenzaldehyde, 500 mg | sc-310503 | 500 mg | $135.00 |