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Piceatannol is a catechol-type polyphenol. The compound may act to act as a protein-tyrosine kinase inhibitor, and preferentially inhibits Syk in comparison to Lyn in in vitro kinase assays. In MCF-10A cell studies, Piceatannol inhibited phorbol ester-induced NF-kappaB activation and cyclooxygenase-2 expression. Research indicates that Piceatannol can upregulate Fas and FasL through AFT2 and Ca2+/p38alpha MAPK-mediated activation of c-Jun pathways. Identified as a potential inhibitor of PKA, PKC, MYLK, Lck, and IKKbeta as well as an activator of SIRT1. SIRT1 is an NAD+ dependent deacetylase that is known to target histone H4. Piceatannol is an inhibitor of CaMK, JNK, IKKalpha and PI 3-kinase. Piceatannol is an activator of caspase-3.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-{[(3-Methylbenzyl)oxy]methyl}piperidine, 500 mg | sc-312149 | 500 mg | $294.00 |