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Paxilline is an indole alkaloid isolated from Penicillium paxilli. Paxilline may act to selectively and reversibly block the high conductance Ca2+-activated K+ channel. In neutrophils, Paxilline blockage of Maxi-K channels decreased the alkalinization of phagocytic vacuoles and inhibited the microbicidal process. When paxilline was applied to the smooth muscle of the rat vas deferens at more positive potentials than -40 mV up to 15 mV, significant depolarization of the smooth muscle contractions was observed. Paxilline is an inhibitor of MaxiKalpha, IP3R and SERCA.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[(2-Fluoro-4-methylsulfonyl)phenoxy]benzoic acid, 500 mg | sc-311987 | 500 mg | $373.00 |