![3-[(2-Chlorophenoxy)methyl]-4-methoxybenzaldehyde - chemical structure image](https://media.scbt.com/product/3--2-chlorophenoxy-methyl-4-methoxybenzaldehyde-structure_22_81_b_228147.jpg)
![3-[(2-Chlorophenoxy)methyl]-4-methoxybenzaldehyde - chemical structure image](https://media.scbt.com/product/3--2-chlorophenoxy-methyl-4-methoxybenzaldehyde-structure_22_81_t_228147.jpg "Molecular structure of 3-[(2-Chlorophenoxy)methyl]-4-methoxybenzaldehyde")
3-[(2-Chlorophenoxy)methyl]-4-methoxybenzaldehyde
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PD 98059 is a potent, selective and reversible cell permeable inhibitor of MEK-1 (MAPKK1 or MAPKs ) that binds to the inactive form of MEK-1, blocking MEK-1 activation and leading to inhibition of phosphorylation and the activation of MAP kinase. In PC12 pheochromocytoma cells, it produced complete blockage of any increase in MAPK activity (IC50 = 2 muM) produced by nerve growth factor. It may act to enhance self-renewal of embryonic stem cells and has been used to unravel the role of the MAPK cascade in biological systems. The compound has been reported to induce GSTA2 (glutathione S-transferase A2) production in H4IIE cells. PD 98059 has also been shown to enhance insulin-mediated increase in glutathione levels as well as, independent of MEK1 inhibition, elevate primary cultured rat hepatocyte glutathione levels.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[(2-Chlorophenoxy)methyl]-4-methoxybenzaldehyde, 500 mg | sc-311980 | 500 mg | $135.00 |