![3-[(2-Bromophenoxy)methyl]piperidine - chemical structure image](https://media.scbt.com/product/3--2-bromophenoxy-methylpiperidine-structure_22_67_b_226769.jpg)
![3-[(2-Bromophenoxy)methyl]piperidine - chemical structure image](https://media.scbt.com/product/3--2-bromophenoxy-methylpiperidine-structure_22_67_t_226769.jpg "Molecular structure of 3-[(2-Bromophenoxy)methyl]piperidine")
3-[(2-Bromophenoxy)methyl]piperidine
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Chelerythrine chloride is an isoquinoline alkaloid. It has been reported to be a potent and selective inhibitor of PKC (protein kinase C, IC50=0.66 muM), and an independent activator of MAPK pathways. The compound has been observed to induce apoptosis in HL-60 human promyelocytic leukemia cells. The proposed method of action of apoptotic stimulation is through the inhibition of binding BclXL to Bax or Bad at an IC50 = 1.5 muM. When used in combination with cisplatin (sc-200896) inhibition of cell proliferation of non-small cell lung cancer cells was increased in an additive/synergistic pattern. Also through inhibition of thromboxane formation and phosphoinositide breakdown chelerythrine chloride was demonstrated to inhibit rabbit platelet aggregation and release. Chelerythrine Chloride is an inhibitor of Cox-2.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[(2-Bromophenoxy)methyl]piperidine, 500 mg | sc-310449 | 500 mg | $294.00 |