3-[(2,3-Dichlorophenoxy)methyl]-4-methoxybenzaldehyde
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Butein is a plant polyphenol that acts as a specific protein tyrosine kinase inhibitor. Butein potently inhibits the tyrosine kinase activity of the EGF receptor (IC50 = 65 muM) and p60c-src (IC50 = 65 muM). The inhibition is competitive with respect to ATP and non-competitive with respect to the substrate. Butein is also a potent antioxidant and antiinflammatory agent which may act to inhibit glutathione reductase and rat liver GST (glutathione-S-transferase (IC50 = 9 muM)). Butein has been reported to activate sirtuins and promote the survival of eukaryotic cells. The Sirtuins, SIRT1-4 and SIRT7 are deacetylases relevant to histone modification. Butein directly inhibits IKK and suggested to also display inhibition towards PDE (c-AMP dependent PDE-IV). Also a potential CYP19 (Aromatase) inhibitor.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
3-[(2,3-Dichlorophenoxy)methyl]-4-methoxybenzaldehyde, 500 mg | sc-312027 | 500 mg | $135.00 |