Date published: 2025-11-9

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(-)-(2R,5S)-1-Allyl-2,5-dimethylpiperazine (CAS 155836-78-5)

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CAS Number:
155836-78-5
Molecular Weight:
154.25
Molecular Formula:
C9H18N2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(−)-(2R,5S)-1-Allyl-2,5-dimethylpiperazine is an important intermediate in the synthesis of delta-opioid receptor ligands. (−)-(2R,5S)-1-Allyl-2,5-dimethylpiperazine is the desired enantiomer in this synthesis and (+)-(2S, 5R)-1-Allyl-2,5-dimethylpiperazine (sc-214097) is the undesired enantiomer.


(-)-(2R,5S)-1-Allyl-2,5-dimethylpiperazine (CAS 155836-78-5) References

  1. 3-(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-alkyl-N-arylbenzamides: potent, non-peptidic agonists of both the micro and delta opioid receptors.  |  Bishop, MJ., et al. 2003. J Med Chem. 46: 623-33. PMID: 12570383
  2. Enantioconvergent synthesis of (-)-(2R,5S)-1-allyl-2,5-dimethylpiperazine, an intermediate to delta-opioid receptor ligands.  |  Janetka, JW., et al. 2003. J Org Chem. 68: 3976-80. PMID: 12737580
  3. Nonpeptidic delta (delta) opioid agonists and antagonists of the diarylmethylpiperazine class: what have we learned?  |  Calderon, SN. 2011. Top Curr Chem. 299: 121-40. PMID: 21630509

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(-)-(2R,5S)-1-Allyl-2,5-dimethylpiperazine, 25 mg

sc-209410
25 mg
$360.00