(2R,4R)-APDC CAS: 169209-63-6
MF: C6H10N2O4
MW: 174.16
A highly selective agonist for group II metabotropic glutamate receptors (mGluR).

(2R,4R)-APDC (CAS 169209-63-6)

(2R,4R)-APDC | CAS 169209-63-6 is rated 5.0 out of 5 by 1.
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Application: (2R,4R)-APDC is a highly selective agonist for group II metabotropic glutamate receptors (mGluR)
CAS Number: 169209-63-6
Purity: >98%
Molecular Weight: 174.16
Molecular Formula: C6H10N2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

(2R,4R)-APDC is a highly potent and highly selective agonist for mGluR-2 (group II metabotropic glutamate receptors). The compound is useful for investigating the functions of metabotropic glutamate receptors in situ. (2R,4R)-APDC inhibits the NADPH-oxidase dependent ROS system. (2R,4R)-APDC is an activator of mGluR-3.


References

1. Schoepp, D.D., et al. 1995. Neuropharmacology. 34: 843-850. PMID: 8532165
2. Monn, J.A., et al. 1996. J. Med. Chem. 39: 2990-3000. PMID: 8709133
3. Mistry, R., et al. 1998. Br. J. Pharmacol. 123: 581-589. PMID: 9504400
4. Attwell, P.J., et al. 1998. Brain Res. 787: 286-291. PMID: 9518652
5. Battaglia, G., et al. 1998. Eur. J. Pharmacol. 356: 271-274. PMID: 9774259
6. Beaver, C.J., et al. 1999. J. Neurophysiol. 82: 86-93. PMID: 10400937
7. Schoepp, D.D., et al. 1999. Neuropharmacology. 38: 1431-1476. PMID: 10530808
8. Gross, O., et al. 2009. Nature. 459: 433-436. PMID: 19339971

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in water.
Storage :
Store at room temperature
Melting Point :
292.77° C (Predicted)
Boiling Point :
377.10° C at 760 mmHg (Predicted)
Density :
1.51 g/cm3 (Predicted)
Refractive Index :
n20D 1.56 (Predicted)
Optical Activity :
α20/D +42.2°, c = 1 in water
IC50 :
mGluR-2: EC5050 = 0.4 µM (human); mGluR-3: EC5050 = 0.4 µM (human); mGluR-1a: EC5050 = > 100 µM (human); mGluR-5: EC5050 = > 100 µM (human); mGluR-4: EC5050 = > 300 µM (human); mGluR-7: EC5050 = > 300 µM (human)
Ki Data :
mGluR-3: Ki= 0.41 µM (human); mGluR-2: Ki= 0.45 µM (human)
pK Values :
pKa: 1.24 (Predicted), pKb: 11.18 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5310984
MDL Number :
MFCD00672677
Beilstein Registry :
7411558
SMILES :
C1[[email protected]@H](NC[[email protected]]1(C(=O)O)N)C(=O)O

Download SDS (MSDS)

Certificate of Analysis

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(2R,4R)-APDC (CAS 169209-63-6)  Product Citations

See how others have used (2R,4R)-APDC (CAS 169209-63-6). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 24121974  Liu, W. et al. 2014. Inflamm. Res. 63: 33-43.

PMID: # 31558613  J. Exp. Med. 216: 2838-2853.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Yao Yao, H. et al. (PubMed 26241549) reported that (2R,4R)-APDC not only has anticonvulsant effect on adult rats with pilocarpine-induced status epilepticus, but also has neuroprotective effect by reducing the abnormal regeneration of nerves. -SCBT Publication Review
Date published: 2015-07-19
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