(2R,4R)-APDC is a highly potent and highly selective agonist for mGluR-2 (group II metabotropic glutamate receptors). The compound is useful for investigating the functions of metabotropic glutamate receptors in situ. (2R,4R)-APDC inhibits the NADPH-oxidase dependent ROS system. (2R,4R)-APDC is an activator of mGluR-3.
1. Schoepp, D.D., et al. 1995. Neuropharmacology. 34: 843-850. PMID: 8532165 2. Monn, J.A., et al. 1996. J. Med. Chem. 39: 2990-3000. PMID: 8709133 3. Mistry, R., et al. 1998. Br. J. Pharmacol. 123: 581-589. PMID: 9504400 4. Attwell, P.J., et al. 1998. Brain Res. 787: 286-291. PMID: 9518652 5. Battaglia, G., et al. 1998. Eur. J. Pharmacol. 356: 271-274. PMID: 9774259 6. Beaver, C.J., et al. 1999. J. Neurophysiol. 82: 86-93. PMID: 10400937 7. Schoepp, D.D., et al. 1999. Neuropharmacology. 38: 1431-1476. PMID: 10530808 8. Gross, O., et al. 2009. Nature. 459: 433-436. PMID: 19339971
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YaoYao, H. et al. (PubMed 26241549) reported that (2R,4R)-APDC not only has anticonvulsant effect on adult rats with pilocarpine-induced status epilepticus, but also has neuroprotective effect by reducing the abnormal regeneration of nerves. -SCBT Publication Review
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