(2′S)-2′-Deoxy-2′-fluoro-5-ethynyluridine (CAS 95740-26-4)
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(2′S)-2′-Deoxy-2′-fluoro-5-ethynyluridine is a nucleoside analog that functions as a potent inhibitor of RNA synthesis. It exerts its mechanism of action by being incorporated into nascent RNA chains, leading to premature termination of RNA transcription. (2′S)-2′-Deoxy-2′-Fluoro-5-Ethynyluridine disrupts the elongation of RNA chains by RNA polymerase, ultimately inhibiting the synthesis of RNA. By interfering with the transcription process, (2′S)-2′-Deoxy-2′-fluoro-5-ethynyluridine can be used to study the regulation of gene expression and the role of specific RNA molecules in cellular processes. Its ability to selectively inhibit RNA synthesis may be useful for investigating the molecular mechanisms underlying gene expression and RNA processing.
(2′S)-2′-Deoxy-2′-fluoro-5-ethynyluridine (CAS 95740-26-4) References
- Dynamic metabolic labeling of DNA in vivo with arabinosyl nucleosides. | Neef, AB. and Luedtke, NW. 2011. Proc Natl Acad Sci U S A. 108: 20404-9. PMID: 22143759
- Metabolic labeling of DNA by purine analogues in vivo. | Neef, AB., et al. 2012. Chembiochem. 13: 1750-3. PMID: 22815258
- DNA labeling in vivo: quantification of epidermal stem cell chromatin content in whole mouse hair follicles using Fiji image processing software. | Carrasco, E., et al. 2014. Methods Mol Biol. 1094: 79-88. PMID: 24162981
- Sonoporation increases therapeutic efficacy of inducible and constitutive BMP2/7 in vivo gene delivery. | Feichtinger, GA., et al. 2014. Hum Gene Ther Methods. 25: 57-71. PMID: 24164605
- Live-cell stimulated Raman scattering imaging of alkyne-tagged biomolecules. | Hong, S., et al. 2014. Angew Chem Int Ed Engl. 53: 5827-31. PMID: 24753329
- Live-cell bioorthogonal Raman imaging. | Hong, S., et al. 2015. Curr Opin Chem Biol. 24: 91-6. PMID: 25461727
- A Bioorthogonal Chemical Reporter of Viral Infection. | Neef, AB., et al. 2015. Angew Chem Int Ed Engl. 54: 7911-4. PMID: 25974835
- Presynaptic partner selection during retinal circuit reassembly varies with timing of neuronal regeneration in vivo. | Yoshimatsu, T., et al. 2016. Nat Commun. 7: 10590. PMID: 26838932
- In Vivo and In Situ Replication Labeling Methods for Super-resolution Structured Illumination Microscopy of Chromosome Territories and Chromatin Domains. | Miron, E., et al. 2016. Methods Mol Biol. 1431: 127-40. PMID: 27283306
- Vagus Motor Neuron Topographic Map Determined by Parallel Mechanisms of hox5 Expression and Time of Axon Initiation. | Barsh, GR., et al. 2017. Curr Biol. 27: 3812-3825.e3. PMID: 29225029
- DNA template strand segregation in developing zebrafish. | Glasauer, SMK., et al. 2021. Cell Chem Biol. 28: 1638-1647.e4. PMID: 34592171
- Replication Labeling Methods for Super-Resolution Imaging of Chromosome Territories and Chromatin Domains. | Miron, E., et al. 2022. Methods Mol Biol. 2476: 111-128. PMID: 35635700
- DNA repair during nonreductional meiosis in the asexual rotifer Adineta vaga. | Terwagne, M., et al. 2022. Sci Adv. 8: eadc8829. PMID: 36449626
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(2′S)-2′-Deoxy-2′-fluoro-5-ethynyluridine, 25 mg | sc-500350 | 25 mg | $714.00 |