Molecular structure of 2′-O-Methyladenosine, CAS Number: 2140-79-6
2′-O-Methyladenosine (CAS 2140-79-6)
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Application:
2′-O-Methyladenosine is an analog of adenosine
CAS Number:
2140-79-6
Purity:
≥98%
Molecular Weight:
281.27
Molecular Formula:
C11H15N5O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2′-O-Methyladenosine is an analog of adenosine used to prepare nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase. 2′-O-Methyladenosine (2′-OMeA) is a nucleoside modification present in eukaryotes like mammals, plants, and fungi. Derived from adenosine, a nucleoside comprising adenine and ribose sugar, 2′-O-Methyladenosine replaces the ribose sugar with a methyl group at the 2′ position. It holds significance in various biological processes, including gene expression, RNA processing, and epigenetic regulation. Notably, it plays a role in the modulation of chromatin structure and DNA methylation, making it valuable for studying these regulatory mechanisms.
2′-O-Methyladenosine (CAS 2140-79-6) References
- THE DIRECT PREPARATION OF 2'-O-METHYLADENOSINE FROM ADENOSINE. | BROOM, AD. and ROBINS, RK. 1965. J Am Chem Soc. 87: 1145-6. PMID: 14284632
- 2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase. | Dong, H., et al. 2012. PLoS Pathog. 8: e1002642. PMID: 22496660
- The 2'-O-methyladenosine nucleoside modification gene OsTRM13 positively regulates salt stress tolerance in rice. | Wang, Y., et al. 2017. J Exp Bot. 68: 1479-1491. PMID: 28369540
- Structural and Energetic Effects of O2'-Ribose Methylation of Protonated Purine Nucleosides. | He, CC., et al. 2018. J Phys Chem B. 122: 9147-9160. PMID: 30203656
- FTSJ1 regulates tRNA 2'-O-methyladenosine modification and suppresses the malignancy of NSCLC via inhibiting DRAM1 expression. | He, Q., et al. 2020. Cell Death Dis. 11: 348. PMID: 32393790
- A comprehensive review of m6A/m6Am RNA methyltransferase structures. | Oerum, S., et al. 2021. Nucleic Acids Res. 49: 7239-7255. PMID: 34023900
- Mass Spectrometry-Based Targeted Serum Monomethylated Ribonucleosides Profiling for Early Detection of Breast Cancer. | Fang, Z., et al. 2021. Front Mol Biosci. 8: 741603. PMID: 34513933
- HILIC-MS/MS for the Determination of Methylated Adenine Nucleosides in Human Urine. | Guo, C., et al. 2021. Anal Chem. 93: 17060-17068. PMID: 34902250
- RNA 2'-O-Methyltransferase Fibrillarin Facilitates Virus Entry Into Macrophages Through Inhibiting Type I Interferon Response. | Li, P., et al. 2022. Front Immunol. 13: 793582. PMID: 35464456
- Methyladenosine Modification in RNAs: From Regulatory Roles to Therapeutic Implications in Cancer. | Qu, X., et al. 2022. Cancers (Basel). 14: PMID: 35804965
- Determination of adenosine and its modifications in urine and plasma from breast cancer patients by hydrophilic interaction liquid chromatography-tandem mass spectrometry. | Zhang, X., et al. 2022. J Chromatogr B Analyt Technol Biomed Life Sci. 1209: 123428. PMID: 36041348
- Simultaneous Determination of Methylated Nucleosides by HILIC-MS/MS Revealed Their Alterations in Urine from Breast Cancer Patients. | Fang, Z., et al. 2022. Metabolites. 12: PMID: 36295875
- A simple method of the preparation of 2'-O-methyladenosine. Methylation of adenosine with methyl iodide in anhydrous alkaline medium. | Yano, J., et al. 1980. Biochim Biophys Acta. 629: 178-83. PMID: 7370305
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Imp4.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2′-O-Methyladenosine, 5 mg | sc-220824 | 5 mg | $102.00 | |||
2′-O-Methyladenosine, 100 mg | sc-220824A | 100 mg | $247.00 |