2'-MeCCPA is a potent and highly selective agonist at Adenosine A1-R (Ki values are 3.3, 9580, 37600 and 1150 nM for human recombinant Adenosine A1-R, Adenosine A2A-R, Adenosine A2B-R and Adenosine A3-R, respectively). 2'-MeCCPA acts as a full agonist. This compound inhibits forskolin-stimulated adenylyl cyclase activity with an IC50 value of 13.1 nM.
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2. Cappellacci, L., et al. 2005. J. Med. Chem. 48: 1550-1562. PMID: 15743197
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