2′-Deoxyguanosine-13C10,15N5 (CAS 961-07-9 (unlabeled))

2′-Deoxyguanosine-13C10,15N5 is a modified form of the nucleoside 2′-deoxyguanosine, where specific carbon and nitrogen isotopes have been incorporated into the molecule. The notation "13C10,15N5" indicates that 10 carbon atoms are replaced with the carbon-13 isotope (^13C), and 5 nitrogen atoms are replaced with the nitrogen-15 isotope (^15N). Isotopically labeled compounds like 2′-Deoxyguanosine-13C10,15N5 are used in various research fields, including metabolomics, proteomics, and nucleic acid studies. They serve as valuable tools for tracing metabolic pathways, studying cellular processes, and investigating molecular interactions. 2′-Deoxyguanosine-13C10,15N5 can be incorporated into DNA molecules during synthesis or enzymatic reactions. The isotopic labeling allows researchers to track the fate and behavior of specific nucleotides within the DNA structure. This can be particularly useful in studying DNA replication, DNA-protein interactions, or DNA damage and repair mechanisms. Furthermore, isotopically labeled nucleotides are utilized in techniques such as stable isotope labeling by amino acids in cell culture (SILAC) or stable isotope labeling with amino acids in mammals (SILAM), where metabolic labeling is applied to track protein synthesis and turnover rates.