Molecular structure of 2′-Deoxyadenosine, CAS Number: 958-09-8
2′-Deoxyadenosine (CAS 958-09-8)
Alternate Names:
DNA nucleoside A
Application:
2′-Deoxyadenosine is a nucleoside adenosine derivative with mutagenic properties
CAS Number:
958-09-8
Purity:
≥98%
Molecular Weight:
251.24
Molecular Formula:
C10H13N5O3
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2′-Deoxyadenosine, also called DNA nucleoside A, is a nucleoside adenosine derivative. 2′-Deoxyadenosine pairs with deoxythymidine (T) in double-stranded DNA. In absence of adenosine deaminase (ADA) it accumulates in T lymphocytes and kills these cells resulting in a genetic disorder known as adenosine deaminase severe combined immunodeficiency disease (ADA-SCID).
2′-Deoxyadenosine (CAS 958-09-8) References
- Identification and characterization of 2'-deoxyadenosine adducts formed by isoprene monoepoxides in vitro. | Begemann, P., et al. 2011. Chem Res Toxicol. 24: 1048-61. PMID: 21548641
- Synthesis of C8-arylamine-modified 2'-deoxyadenosine phosphoramidites and their site-specific incorporation into oligonucleotides. | Szombati, Z., et al. 2012. Chembiochem. 13: 700-12. PMID: 22378348
- Effects of substitutions at the 4' and 2 positions on the bioactivity of 4'-ethynyl-2-fluoro-2'-deoxyadenosine. | Kirby, KA., et al. 2013. Antimicrob Agents Chemother. 57: 6254-64. PMID: 24100493
- Detection of Bulky Endogenous Oxidative DNA Lesions Derived from 8,5'-Cyclo-2'-deoxyadenosine by ³²P-Postlabeling Assay. | Zhou, GD. and Moorthy, B. 2015. Curr Protoc Toxicol. 64: 17.17.1-17.17.14. PMID: 26344223
- Influence of Sodium Cationization versus Protonation on the Gas-Phase Conformations and Glycosidic Bond Stabilities of 2'-Deoxyadenosine and Adenosine. | Zhu, Y., et al. 2016. J Phys Chem B. 120: 8892-904. PMID: 27494378
- MK-8591 (4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine) Exhibits Potent Activity against HIV-2 Isolates and Drug-Resistant HIV-2 Mutants in Culture. | Wu, VH., et al. 2017. Antimicrob Agents Chemother. 61: PMID: 28559249
- [Simultaneous determination of cordycepin and 2'-deoxyadenosine in Cordyceps genus by online SPE-HPLC]. | Tian, Y., et al. 2017. Zhongguo Zhong Yao Za Zhi. 42: 1932-1938. PMID: 29090553
- Exploring the binding modes of cordycepin to human adenosine deaminase 1 (ADA1) compared to adenosine and 2'-deoxyadenosine. | Niramitranon, J. and Pongprayoon, P. 2020. J Mol Model. 26: 29. PMID: 31953681
- Composite Hydrogel Microspheres Encapsulating Hollow Mesoporous Imprinted Nanoparticles for Selective Capture and Separation of 2'-Deoxyadenosine. | Liu, L., et al. 2022. Molecules. 27: PMID: 36364271
- Metabolic stress-induced human beta-cell death is mediated by increased intracellular levels of adenosine. | Ngamjariyawat, A., et al. 2023. Front Endocrinol (Lausanne). 14: 1060675. PMID: 36761184
- Production of Modified Nucleosides in a Continuous Enzyme Membrane Reactor. | Thiele, I., et al. 2023. Int J Mol Sci. 24: PMID: 37047056
- Screening the Thermotoga maritima genome for new wide-spectrum nucleoside and nucleotide kinases. | Winkler, KF., et al. 2023. J Biol Chem. 299: 104746. PMID: 37094698
- N6-methyl-2'-deoxyadenosine promotes self-renewal of BFU-E progenitor in erythropoiesis. | Li, Y., et al. 2023. iScience. 26: 106924. PMID: 37283807
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2′-Deoxyadenosine, 5 g | sc-275525 | 5 g | $39.00 | |||
2′-Deoxyadenosine, 10 g | sc-275525A | 10 g | $70.00 | |||
2′-Deoxyadenosine, 25 g | sc-275525B | 25 g | $164.00 | |||
2′-Deoxyadenosine, 100 g | sc-275525C | 100 g | $607.00 |