2prime,7prime-Dichlorofluorescein diacetate 2′,7′-Dichlorofluorescein diacetate is a cell-permeable fluorogenic ROS probe.

2′,7′-Dichlorofluorescein diacetate (CAS 2044-85-1)

2′,7′-Dichlorofluorescein diacetate | CAS 2044-85-1 is rated 4.0 out of 5 by 2.
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Alternate Names: Diacetyldichlorofluorescein; DCFDA
Application: 2′,7′-Dichlorofluorescein diacetate is a cell-permeable fluorogenic ROS probe
CAS Number: 2044-85-1
Purity: ≥95%
Molecular Weight: 485.27
Molecular Formula: C24H14Cl2O7
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

2′,7′-Dichlorofluorescein diacetate is a cell-permeable fluorogenic probe that is useful for the detection of reactive oxygen species (ROS) and nitric oxide (NO) and for the determination of the degree of overall oxidative stress.

Physical State :
Solid
Solubility :
Soluble in DMSO and acetone. Insoluble in water.
Storage :
Store at -20° C
Melting Point :
232-234° C (lit.)
Boiling Point :
675.91° C at 760 mmHg (Predicted)
Density :
1.59 g/cm3 (Predicted)
Refractive Index :
n20D 1.69 (Predicted)
Fluoresence :
λex 504 nm, λem 524 nm in 0.1 M Tris pH 8.0 (esterase) after hydrolysis.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
104913
MDL Number :
MFCD00037501
Beilstein Registry :
68488
SMILES :
CC(=O)OC1=C(C=C2C(=C1)OC3=CC(=C(C=C3C24C5=CC=CC=C5C(=O)O4)Cl)OC(=O)C)Cl

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2prime,7prime-Dichlorofluorescein diacetate (CAS 2044-85-1) Product Citations

See how others have used 2prime,7prime-Dichlorofluorescein diacetate (CAS 2044-85-1). Click on the entry to view the PubMed entry .

Citations 1 to 10 of 11 total

PMID: # 29225138  Jeong, M.|Kim, HM.|Ahn, JH.|Lee, KT.|Jang, DS.|Choi, JH.| et al. 2018. Chem. Biol. Interact. 280: 99-108.

PMID: # 28430433  Acharya, S. et al. 2017. J. Agric. Food Chem. 65: 3636-3646.

PMID: # 26647977  Shi, XY. et al. 2016. Mol Med Rep. 13: 744-52.

PMID: # 26276565  Pandurangan, M. et al. 2016. Biol Trace Elem Res. 170: 309-19.

PMID: # 26985734  Pandurangan, M. et al. 2016. J. Photochem. Photobiol. B, Biol. 158: 206-11.

PMID: # 26235438  Wen, H. et al. 2015. Biochim. Biophys. Acta. 1853: 2937-44.

PMID: # 25216701  Ahn, JH. et al. 2015. J. Cancer Res. Clin. Oncol. 141: 255-68.

PMID: # 26567798  Martinez-Gil, N. et al. 2015. Investigative ophthalmology & visual science. 56: 6855-63.

PMID: # 31790883  J. Photochem. Photobiol. B, Biol. 202: 111718.

PMID: # 32450254  Biochem. Pharmacol. 114054.

Citations 1 to 10 of 11 total
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Rated 3 out of 5 by from Works but not perfectly I used DCFDA to detect ROS before and after H2O2 treatment. It penetrated cells and stained them, but it didn't seem to differentiate between H2O2 treated and controls and failed to produce the results produced by using DCFDA from another source
Date published: 2018-01-07
Rated 5 out of 5 by from Various publications cite the use of 2' Various publications cite the use of 2',7'-Dichlorofluorescein diacetate (DCFDA), a cell-permeable fluorogenic probe, for the detection of reactive oxygen species (ROS) and nitric oxide (NO) and for the determination of the degree of overall oxidative stress. -SCBT Publication Review
Date published: 2015-01-22
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