Molecular structure of 2′,7′-bis(2-Carboxyethyl)-5(6)-carboxyfluorescein, CAS Number: 85138-49-4
2′,7′-bis(2-Carboxyethyl)-5(6)-carboxyfluorescein (CAS 85138-49-4)
See product citations (3)
Alternate Names:
BCECF
Application:
2′,7′-bis(2-Carboxyethyl)-5(6)-carboxyfluorescein is Fluorescent cytoplasmic pH indicator
CAS Number:
85138-49-4
Purity:
≥90%
Molecular Weight:
520.44
Molecular Formula:
C27H20O11
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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2′,7′-bis(2-Carboxyethyl)-5(6)-carboxyfluorescein (BCECF) is a widely used fluorescent indicator for the measurement of cytoplasmic pH in cells. BCECF has been used to: observe regulation of basal acid secretion by glycogen synthase kinase 3, identify enzymatic activity, determine transport activity in human erythrocytes, observe Na+/H+ exchange activity and regulation of gastric acid release.
2′,7′-bis(2-Carboxyethyl)-5(6)-carboxyfluorescein (CAS 85138-49-4) References
- Drug efflux transport properties of 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester (BCECF-AM) and its fluorescent free acid, BCECF. | Bachmeier, CJ., et al. 2004. J Pharm Sci. 93: 932-42. PMID: 14999730
- Polarized efflux of 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein from cultured epithelial cell monolayers. | Collington, GK., et al. 1992. Biochem Pharmacol. 44: 417-24. PMID: 1510694
- Pharmacological profile of inhibition of 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein efflux in human HCT-8 intestinal epithelial cells. | Collington, GK., et al. 1991. Biochem Pharmacol. 42 Suppl: S33-8. PMID: 1768283
- Regulation of gastric acid secretion by PKB/Akt2. | Rotte, A., et al. 2010. Cell Physiol Biochem. 25: 695-704. PMID: 20511715
- Direct quantification of bacterial biomass in influent, effluent and activated sludge of wastewater treatment plants by using flow cytometry. | Foladori, P., et al. 2010. Water Res. 44: 3807-18. PMID: 20537673
- Regulation of basal gastric acid secretion by the glycogen synthase kinase GSK3. | Rotte, A., et al. 2010. J Gastroenterol. 45: 1022-32. PMID: 20552232
- Upregulation of Na+/H+ exchanger by the AMP-activated protein kinase. | Rotte, A., et al. 2010. Biochem Biophys Res Commun. 398: 677-82. PMID: 20609358
- 8-Prenylnaringenin is an inhibitor of multidrug resistance-associated transporters, P-glycoprotein and MRP1. | Wesołowska, O., et al. 2010. Eur J Pharmacol. 644: 32-40. PMID: 20633549
- The phosphoinositide PI(3,5)P2 inhibits the activity of plant NHX proton/potassium antiporters: Advantages of a novel electrophysiological approach. | Gradogna, A., et al. 2022. Biomol Concepts. 13: 119-125. PMID: 35286784
- Cytoplasmic pH and free Mg2+ in lymphocytes. | Rink, TJ., et al. 1982. J Cell Biol. 95: 189-96. PMID: 6815204
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2′,7′-bis(2-Carboxyethyl)-5(6)-carboxyfluorescein, 1 mg | sc-202883 | 1 mg | $144.00 |