2′,4′-Dihydroxychalcone (CAS 1776-30-3)
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2′,4′-Dihydroxychalcone is a natural flavonoid present in various plant sources, including chamomile, licorice, and ginger. This polyphenolic compound has garnered attention for its potential antioxidant and anti-inflammatory properties. Furthermore, it has been investigated for its anti-cancer potential and its ability to inhibit the growth of specific bacterial strains. While the precise mechanism of action for 2′,4′-dihydroxychalcone remains partially understood, studies have proposed that it may function as an antioxidant and anti-inflammatory agent by impeding the production of inflammatory mediators, including nitric oxide and prostaglandins. Moreover, it may induce apoptosis, or programmed cell death, in cancer cells, thus exhibiting anti-cancer effects. Furthermore, 2′,4′-dihydroxychalcone may hinder bacterial growth by interfering with their cell wall synthesis.
2′,4′-Dihydroxychalcone (CAS 1776-30-3) References
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- Preliminary studies on anti-tumor activity of 2',4'-dihydroxychalcone isolated from Herba Oxytropis in human gastric cancer MGC-803 cells. | Lou, C., et al. 2009. Toxicol In Vitro. 23: 906-10. PMID: 19457454
- Susceptibility of Staphylococcus aureus strains toward combinations of oxacillin-2,4-dihydroxychalcone. | Talia, JM., et al. 2009. Folia Microbiol (Praha). 54: 516-20. PMID: 20140719
- 2',4'-Dihydroxychalcone-induced apoptosis of human gastric cancer MGC-803 cells via down-regulation of survivin mRNA. | Lou, C., et al. 2010. Toxicol In Vitro. 24: 1333-7. PMID: 20471467
- Interaction between 2',4-dihydroxychalcone and the N, f, e conformers of bovine serum albumin: influence of temperature and ionic strength. | Curvale, RA., et al. 2012. Protein J. 31: 293-9. PMID: 22450828
- Synthesis of 2,4-dihydroxychalcone derivatives as potential antidepressant effect. | Guan, LP., et al. 2013. Drug Res (Stuttg). 63: 46-51. PMID: 23447048
- Regiospecificity of human UDP-glucuronosyltransferase isoforms in chalcone and flavanone glucuronidation determined by metal complexation and tandem mass spectrometry. | Niemeyer, ED. and Brodbelt, JS. 2013. J Nat Prod. 76: 1121-32. PMID: 23713759
- 2,4-Dihydroxychalcone derivatives as novel potent cell division cycle 25B phosphatase inhibitors and protein tyrosine phosphatase 1B inhibitors. | Xie, C., et al. 2014. Pharmazie. 69: 257-62. PMID: 24791588
- The 2',4'-dihydroxychalcone could be explored to develop new inhibitors against the glycerol-3-phosphate dehydrogenase from Leishmania species. | Passalacqua, TG., et al. 2015. Bioorg Med Chem Lett. 25: 3564-8. PMID: 26169126
- In Vitro Antifungal Activity and Mode of Action of 2',4'-Dihydroxychalcone against Aspergillus fumigatus. | Seo, YH., et al. 2015. Mycobiology. 43: 150-6. PMID: 26190922
- 2',4'-dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC-3 human prostate cancer cell growth by induction of apoptosis. | Sheng, Y., et al. 2015. Oncol Lett. 10: 3737-3741. PMID: 26788200
- Theoretical and Experimental Study of Inclusion Complexes of β-Cyclodextrins with Chalcone and 2',4'-Dihydroxychalcone. | Sancho, MI., et al. 2016. J Phys Chem B. 120: 3000-11. PMID: 26950264
- Synthesis and Evaluation of Novel Oxyalkylated Derivatives of 2',4'-Dihydroxychalcone as Anti-Oomycete Agents against Bronopol Resistant Strains of Saprolegnia sp. | Flores, S., et al. 2016. Int J Mol Sci. 17: PMID: 27556457
- Identification of 2',4'-Dihydroxychalcone as an Antivirulence Agent Targeting HlyU, a Master Virulence Regulator in Vibrio vulnificus. | Imdad, S., et al. 2018. Molecules. 23: PMID: 29925801
- Plant- and Bacteria-Derived Compounds with Anti-Philasterides dicentrarchi Activity. | Sueiro, RA., et al. 2022. Pathogens. 11: PMID: 35215209
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2′,4′-Dihydroxychalcone, 1 g | sc-266263 | 1 g | $428.00 |