Molecular structure of 2′,2′-Difluoro-2′-deoxyuridine, CAS Number: 114248-23-6
2′,2′-Difluoro-2′-deoxyuridine (CAS 114248-23-6)
See product citations (2)
Alternate Names:
2′-Deoxy-2′,2′-difluorouridine; 2,2-Difluorodeoxyuridine
Application:
2′,2′-Difluoro-2′-deoxyuridine is a metabolite product of gemcitabine
CAS Number:
114248-23-6
Purity:
97%
Molecular Weight:
264.18
Molecular Formula:
C9H10F2N2O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A metabolite product of Gemcitabine.
2′,2′-Difluoro-2′-deoxyuridine (CAS 114248-23-6) References
- Modulation of gemcitabine (2',2'-difluoro-2'-deoxycytidine) pharmacokinetics, metabolism, and bioavailability in mice by 3,4,5,6-tetrahydrouridine. | Beumer, JH., et al. 2008. Clin Cancer Res. 14: 3529-35. PMID: 18519786
- A phase I clinical, plasma, and cellular pharmacology study of gemcitabine. | Abbruzzese, JL., et al. 1991. J Clin Oncol. 9: 491-8. PMID: 1999720
- Modulatory activity of 2',2'-difluorodeoxycytidine on the phosphorylation and cytotoxicity of arabinosyl nucleosides. | Gandhi, V. and Plunkett, W. 1990. Cancer Res. 50: 3675-80. PMID: 2340517
- Inhibition of thymidylate synthase by 2',2'-difluoro-2'-deoxycytidine (Gemcitabine) and its metabolite 2',2'-difluoro-2'-deoxyuridine. | Honeywell, RJ., et al. 2015. Int J Biochem Cell Biol. 60: 73-81. PMID: 25562513
- Preanalytical Stability of Gemcitabine and its Metabolite 2', 2'-Difluoro-2'-Deoxyuridine in Whole Blood-Assessed by Liquid Chromatography Tandem Mass Spectrometry. | Bjånes, T., et al. 2015. J Pharm Sci. 104: 4427-4432. PMID: 26372902
- LC-MS/MS method for quantitation of gemcitabine and its metabolite 2',2'-difluoro-2'-deoxyuridine in mouse plasma and brain tissue: Application to a preclinical pharmacokinetic study. | Zhong, B., et al. 2021. J Pharm Biomed Anal. 198: 114025. PMID: 33744463
- Cytosine arabinoside influx and nucleoside transport sites in acute leukemia. | Wiley, JS., et al. 1982. J Clin Invest. 69: 479-89. PMID: 6948829
- Determination of the antimetabolite Gemcitabine (2',2'-difluoro-2'-deoxycytidine) and of 2',2'-difluoro-2'-deoxyuridine by 19F nuclear magnetic resonance spectroscopy. | Edzes, HT., et al. 1993. Anal Biochem. 214: 25-30. PMID: 8250231
- Characterization of a novel Na+-dependent, guanosine-specific, nitrobenzylthioinosine-sensitive transporter in acute promyelocytic leukemia cells. | Flanagan, SA. and Meckling-Gill, KA. 1997. J Biol Chem. 272: 18026-32. PMID: 9218431
- Development and validation of an ion pair HPLC method for gemcitabine and 2′, 2′-difluoro-2′-deoxyuridine determination | Losa, R., Sierra, M. I., Guardado, C., Fernandez, A., Gión, M. O., Blanco, D., & Buesa, J. M. 2005. Analytica chimica acta. 528(2): 255-260.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2′,2′-Difluoro-2′-deoxyuridine, 5 mg | sc-220827 | 5 mg | $430.00 |