26S Proteasome p54 Antibody (439): sc-65746

26S Proteasome p54 Antibody (439) is a mouse monoclonal IgG1 antibody that detects 26S proteasome p54 in human species by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). 26S proteasome p54 is a crucial component of the 19S regulatory complex of the 26S proteasome, which is essential for the degradation of ubiquitinated proteins within eukaryotic cells. Anti-26S proteasome p54 antibody (439) plays a significant role in maintaining cellular homeostasis by regulating the turnover of various proteins, thereby influencing numerous biological processes such as cell cycle progression, apoptosis, and stress responses. 26S proteasome p54 specifically binds to multiubiquitin chains, facilitating the recognition and processing of substrates destined for degradation. Notably, 26S proteasome p54 interaction with non-proteasomal proteins, including HSP 82, Smt3, and UBC9, highlights involvement in broader cellular pathways beyond proteolysis, suggesting a multifaceted role in cellular regulation. 26S proteasome p54 functionality is also influenced by structural integrity, as the presence of zinc can lead to dissociation from the 19S complex, resulting in the loss of peptidase activity. This intricate balance underscores the importance of 26S proteasome p54 in cellular function and potential as a target for therapeutic interventions in diseases characterized by proteostasis dysregulation.

The preferred 26S Proteasome p54 antibody is 26S Proteasome p54 Antibody (28): sc-65748.