(25S)-delta7-Dafachronic acid (CAS 949004-12-0)
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(25S)-delta7-Dafachronic acid is a ligand of the nuclear hormone receptor DAF-12, which plays a significant role in the regulation of development, metabolism, and longevity in nematodes, particularly in Caenorhabditis elegans. Researchers utilize this compound to study the signaling pathways that govern these biological processes. In the field of developmental biology, it′s used to understand how hormone signaling can influence the decision of larvae to either continue development or enter into a dormant state known as dauer. This acid is also a tool in aging research, as manipulating DAF-12 signaling with (25S)-delta7-Dafachronic acid provides insights into the molecular mechanisms underlying aging and lifespan. Its role in metabolic regulation is another area of interest, with studies focusing on how DAF-12 and its ligands impact fat metabolism and general homeostasis.
(25S)-delta7-Dafachronic acid (CAS 949004-12-0) References
- A Natural Mutational Event Uncovers a Life History Trade-Off via Hormonal Pleiotropy. | Billard, B., et al. 2020. Curr Biol. 30: 4142-4154.e9. PMID: 32888477
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(25S)-delta7-Dafachronic acid, 100 µg | sc-364091 | 100 µg | $321.00 |