25-Hydroxycholesterol (CAS 2140-46-7)
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25-Hydroxycholesterol is a bioactive lipid molecule that has become a key subject of study in the field of lipidomics and cellular signaling. It is naturally occurring and acts as an intermediate in the biosynthetic pathway of various oxysterols. Within research applications, it is examined for its role in modulating membrane fluidity and influencing lipid-raft formation, which has implications for cellular signaling and trafficking. Additionally, scientists are interested in its regulatory role on sterol-responsive genes, which is fundamental in understanding cholesterol metabolism at the molecular level. The impact of 25-Hydroxycholesterol on the function of immune cells is another area of active research, particularly in deciphering signal transduction pathways that mediate inflammatory responses. Moreover, it serves as a standard in the analytical quantification of sterols in complex biological samples, which is essential for studies on cholesterol homeostasis and lipid metabolism disorders.
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25-Hydroxycholesterol (CAS 2140-46-7) References
- Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. | Adams, CM., et al. 2004. J Biol Chem. 279: 52772-80. PMID: 15452130
- 25-Hydroxycholesterol secreted by macrophages in response to Toll-like receptor activation suppresses immunoglobulin A production. | Bauman, DR., et al. 2009. Proc Natl Acad Sci U S A. 106: 16764-9. PMID: 19805370
- On the formation and possible biological role of 25-hydroxycholesterol. | Diczfalusy, U. 2013. Biochimie. 95: 455-60. PMID: 22732193
- Sulfation of 25-hydroxycholesterol regulates lipid metabolism, inflammatory responses, and cell proliferation. | Ren, S. and Ning, Y. 2014. Am J Physiol Endocrinol Metab. 306: E123-30. PMID: 24302009
- 25-Hydroxycholesterol acts as an amplifier of inflammatory signaling. | Gold, ES., et al. 2014. Proc Natl Acad Sci U S A. 111: 10666-71. PMID: 24994901
- Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon. | Reboldi, A., et al. 2014. Science. 345: 679-84. PMID: 25104388
- 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model. | Li, C., et al. 2017. Immunity. 46: 446-456. PMID: 28314593
- 25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor. | Zu, S., et al. 2020. Cell Res. 30: 1043-1045. PMID: 32811977
- Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival. | Cao, Q., et al. 2020. Oxid Med Cell Longev. 2020: 8893305. PMID: 33274010
- 25-Hydroxycholesterol Effect on Membrane Structure and Mechanical Properties. | Domingues, MM., et al. 2021. Int J Mol Sci. 22: PMID: 33806504
- Senolysis induced by 25-hydroxycholesterol targets CRYAB in multiple cell types. | Limbad, C., et al. 2022. iScience. 25: 103848. PMID: 35198901
- TGF-beta 1 and 25-hydroxycholesterol stimulate osteoblast-like vascular cells to calcify. | Watson, KE., et al. 1994. J Clin Invest. 93: 2106-13. PMID: 8182141
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
25-Hydroxycholesterol, 5 mg | sc-214091B | 5 mg | $53.00 | |||
25-Hydroxycholesterol, 10 mg | sc-214091 | 10 mg | $91.00 | |||
25-Hydroxycholesterol, 25 mg | sc-214091A | 25 mg | $169.00 | |||
25-Hydroxycholesterol, 100 mg | sc-214091C | 100 mg | $474.00 |