(24R)-24-Hydroxycalcitriol (CAS 56142-94-0)

(24R)-24-Hydroxycalcitriol is a compound that has been the focus of various research studies in the field of biochemistry, particularly concerning vitamin D metabolism. It is a hydroxylated metabolite of calcitriol, the active form of vitamin D3, and serves as an important molecule for understanding the regulation of calcium and phosphate homeostasis in the body. Researchers are interested in (24R)-24-Hydroxycalcitriol for its role in the vitamin D endocrine system, where it participates in feedback mechanisms that control vitamin D3 levels. Studies involving this hydroxycalcitriol isomer examine its interaction with vitamin D binding proteins and its affinity for vitamin D receptors compared to other metabolites. Additionally, (24R)-24-Hydroxycalcitriol is applied in research to investigate its influence on gene expression related to mineral metabolism, as well as its potential impact on bone formation and resorption. The specific configuration at the 24 position, denoted by the R stereochemistry, is critical for distinguishing its activity from other stereoisomers.