(24R)-24,25-Dihydroxyvitamin D3 (CAS 55721-11-4)
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(24R)-24,25-Dihydroxyvitamin D3 is a vitamin D3 metabolite which is involved in bone ossification. In addition, it is known that (24R)-24,25-Dihydroxyvitamin D3 mediates calcium and phosphorus homeostasis. Also (24R)-24,25-Dihydroxyvitamin D3 inhibits calcium channels in osteosarcoma cells via suppressing the effects of 1alpha, 25-dihydroxyvitamin D3 and testosterone. Alternate studies indicate that (24R)-24,25-Dihydroxyvitamin D3 can decrease the abundance of p53 and Pi-induced cytochrome c translocation. Furthermore, (24R)-24,25-Dihydroxyvitamin D3 can increase cell proliferation in resting zone (RC) chondrocytes and inhibits matrix enzymes by possibly inhibiting the degradation of the matrix.
(24R)-24,25-Dihydroxyvitamin D3 (CAS 55721-11-4) References
- 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] controls growth plate development by inhibiting apoptosis in the reserve zone and stimulating response to 1alpha,25(OH)2D3 in hypertrophic cells. | Boyan, BD., et al. 2010. J Steroid Biochem Mol Biol. 121: 212-6. PMID: 20307662
- 24R,25-Dihydroxyvitamin D3, lysophosphatidic acid, and p53: a signaling axis in the inhibition of phosphate-induced chondrocyte apoptosis. | Hurst-Kennedy, J., et al. 2010. J Steroid Biochem Mol Biol. 122: 264-71. PMID: 20594980
- Serum 25-hydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3 concentrations in adult dogs are more substantially increased by oral supplementation of 25-hydroxyvitamin D3 than by vitamin D3. | Young, LR. and Backus, RC. 2017. J Nutr Sci. 6: e30. PMID: 29152235
- Specific binding of 24R,25-dihydroxyvitamin D3 to chick intestinal mucosa: 24R,25-dihydroxyvitamin D3 is an allosteric effector of 1,25-dihydroxyvitamin D3 binding. | Wilhelm, F., et al. 1986. Arch Biochem Biophys. 249: 88-94. PMID: 3017223
- 24R,25-Dihydroxyvitamin D3 regulates breast cancer cells in vitro and in vivo. | Verma, A., et al. 2019. Biochim Biophys Acta Gen Subj. 1863: 1498-1512. PMID: 31125679
- Interlaboratory comparison of 25-hydroxyvitamin D assays: Vitamin D Standardization Program (VDSP) Intercomparison Study 2 - Part 2 ligand binding assays - impact of 25-hydroxyvitamin D2 and 24R,25-dihydroxyvitamin D3 on assay performance. | Wise, SA., et al. 2022. Anal Bioanal Chem. 414: 351-366. PMID: 34435207
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
(24R)-24,25-Dihydroxyvitamin D3, 50 µg | sc-231276 | 50 µg | $400.00 |