Date published: 2026-4-12

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22-NHC hydrochloride (CAS 360068-87-7)

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Alternate Names:
22-Azacholesterol; (3β)-20S-[(3-Methylbutyl)amino]-pregn-5-en-3-ol
Application:
22-NHC hydrochloride is a hedgehog signaling inhibitor
CAS Number:
360068-87-7
Molecular Weight:
424.10
Molecular Formula:
C26H45NO•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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22-NHC hydrochloride is a compound that functions as a potent N-heterocyclic carbene (NHC) ligand in various catalytic reactions. It acts as a strong σ-donor and can form stable complexes with a wide range of transition metals, facilitating a variety of metal-catalyzed transformations. The mechanism of action of 22-NHC hydrochloride involves its ability to coordinate with metal centers, enhancing their reactivity and selectivity in organic synthesis. 22-Nhc Hydrochloride plays a role in promoting C-C and C-N bond formation, as well as facilitating cross-coupling reactions and other important transformations in chemical synthesis. Its unique structure and electronic properties make it useful for exploring new catalytic processes and developing novel methodologies. 22-NHC hydrochloride serves as an effective ligand for promoting a diverse array of metal-catalyzed reactions, contributing to the advancement of chemistry research.


22-NHC hydrochloride (CAS 360068-87-7) References

  1. Steroidal alkaloids isolated from Veratrum grandiflorum Loes. as novel Smoothened inhibitors with anti-proliferation effects on DAOY medulloblastoma cells.  |  Gao, LJ., et al. 2021. Bioorg Med Chem. 39: 116166. PMID: 33910157

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

22-NHC hydrochloride, 1 mg

sc-396664
1 mg
$72.00

22-NHC hydrochloride, 5 mg

sc-396664A
5 mg
$297.00