Date published: 2025-11-3

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21(R)-Hydroxy Montelukast (CAS 184763-26-6)

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Alternate Names:
[R-[R*,R*-(E)]]-1-[[[1-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxy-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]-cyclopropaneacetic Acid
Application:
21(R)-Hydroxy Montelukast is a benzylic hydroxylated metabolite of Montelukast
CAS Number:
184763-26-6
Molecular Weight:
602.18
Molecular Formula:
C35H36ClNO4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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21(R)-Hydroxy Montelukast is a chemically modified derivative of montelukast, a leukotriene receptor antagonist, primarily distinguished by its specific hydroxylation at the 21st carbon in the R configuration. This structural alteration significantly influences its interaction with leukotriene receptors, potentially altering its affinity or selectivity compared to its parent compound. In research applications, 21(R)-Hydroxy Montelukast serves as a tool for probing the biochemical pathways involved in leukotriene receptor signaling and regulation. Its unique properties enable scientists to dissect the nuanced mechanisms through which leukotrienes influence cellular responses, contributing to a deeper understanding of inflammatory processes at a molecular level. By offering a variant molecular structure, this compound aids in elucidating the role of specific leukotriene receptor subtypes in various signaling pathways, facilitating the exploration of their contributions to cellular and physiological responses in model organisms.


21(R)-Hydroxy Montelukast (CAS 184763-26-6) References

  1. Montelukast dose selection in 6- to 14-year-olds: comparison of single-dose pharmacokinetics in children and adults.  |  Knorr, B., et al. 1999. J Clin Pharmacol. 39: 786-93. PMID: 10434229
  2. In Vitro Metabolism of Montelukast by Cytochrome P450s and UDP-Glucuronosyltransferases.  |  Cardoso, Jde O., et al. 2015. Drug Metab Dispos. 43: 1905-16. PMID: 26374173
  3. Metabolic profiles of montelukast sodium (Singulair), a potent cysteinyl leukotriene1 receptor antagonist, in human plasma and bile.  |  Balani, SK., et al. 1997. Drug Metab Dispos. 25: 1282-7. PMID: 9351905

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

21(R)-Hydroxy Montelukast, 500 µg

sc-206556
500 µg
$600.00