21-Hydroxypregnenolone (CAS 1164-98-3)
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21-Hydroxypregnenolone, a steroid hormone, assumes a pivotal role in the biosynthesis of glucocorticoids and mineralocorticoids within the adrenal gland. Its synthesis occurs through a series of enzymatic reactions, starting from cholesterol, with regulation mediated by the hypothalamic-pituitary-adrenal (HPA) axis. While the precise mechanism of action of 21-hydroxypregnenolone remains incompletely understood, it is believed to exert its effects through multiple targets within the brain, including GABA-A receptors, NMDA receptors, and sigma-1 receptors. As a positive allosteric modulator of GABA-A receptors, it enhances the inhibitory effects of GABA on neuronal activity. Simultaneously, as a negative allosteric modulator of NMDA receptors, it diminishes the excitatory effects of glutamate on neuronal activity. Furthermore, 21-hydroxypregnenolone binds to sigma-1 receptors, which play roles in diverse cellular processes, including neuroprotection and neuroplasticity.
21-Hydroxypregnenolone (CAS 1164-98-3) References
- Inhibition of human steroidogenic cytochrome P450 c17 by 21-hydroxypregnenolone and related steroid hormones. | Niwa, T., et al. 2012. Biol Pharm Bull. 35: 1594-7. PMID: 22975514
- Detection of Urine Metabolites in a Rat Model of Chronic Fatigue Syndrome before and after Exercise. | Shao, C., et al. 2017. Biomed Res Int. 2017: 8182020. PMID: 28421200
- 3 beta-hydroxysteroid isomerase dehydrogenase in guinea-pig kidney: possible involvement in 11-deoxycorticosterone formation in situ. | Devine, PL., et al. 1986. J Steroid Biochem. 25: 265-70. PMID: 3018375
- Therapeutic Effect and Metabolic Mechanism of A Selenium-Polysaccharide from Ziyang Green Tea on Chronic Fatigue Syndrome. | Shao, C., et al. 2018. Polymers (Basel). 10: PMID: 30961194
- Steroid 21-hydroxylation by human preovulatory follicles from stimulated cycles: a mass spectrometrical study of deoxycorticosterone, 21-hydroxypregnenolone and 11-deoxycortisol in follicular fluid. | Dehennin, L., et al. 1987. J Steroid Biochem. 26: 337-43. PMID: 3495701
- A paradox: elevated 21-hydroxypregnenolone production in newborns with 21-hydroxylase deficiency. | Shackleton, CH., et al. 1987. Steroids. 49: 295-311. PMID: 3502660
- Soy-whey dual-protein alleviates osteoporosis of ovariectomized rats via regulating bone fat metabolism through gut-liver-bone axis. | Zhang, J., et al. 2022. Nutrition. 103-104: 111723. PMID: 35843042
- Steroid concentrations in the outer and inner zones of the adrenal cortex of the guinea pig. | Nishikawa, T. and Strott, CA. 1984. J Steroid Biochem. 20: 1123-7. PMID: 6233457
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
21-Hydroxypregnenolone, 250 mg | sc-488193 | 250 mg | $218.00 |