Molecular structure of 21-Deoxycortisol, CAS Number: 641-77-0
21-Deoxycortisol (CAS 641-77-0)
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Alternate Names:
11β,17α-Dihydroxy-4-pregnene-3,20-dione; 11β,17α-Dihydroxyprogesterone; 21-Desoxycortisol
CAS Number:
641-77-0
Molecular Weight:
346.46
Molecular Formula:
C21H30O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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21-Deoxycortisol is a steroid hormone that acts as an intermediate in the biosynthesis of cortisol, a glucocorticoid hormone. It is produced in the adrenal cortex and plays a role in the regulation of metabolism, immune response, and stress. 21-Deoxycortisol functions as a precursor molecule in the synthesis of cortisol. Its mechanism of action involves being converted into cortisol through a series of enzymatic reactions, leading to the production of the active hormone. This conversion process occurs at the molecular level within the adrenal glands, where specific enzymes catalyze the transformation of 21-Deoxycortisol into cortisol. 21-Deoxycortisol serves as a intermediate in the biosynthetic pathway of cortisol, contributing to the overall regulation of physiological processes.
21-Deoxycortisol (CAS 641-77-0) References
- Plasma 21-deoxycortisol: comparison of a time-resolved fluoroimmunoassay using a biotinylated tracer with a radioimmunossay using (125)iodine. | Fiet, J., et al. 2000. J Steroid Biochem Mol Biol. 72: 55-60. PMID: 10731638
- Serum 21-Deoxycortisol, 17-Hydroxyprogesterone, and 11-deoxycortisol in classic congenital adrenal hyperplasia: clinical and hormonal correlations and identification of patients with 11beta-hydroxylase deficiency among a large group with alleged 21-hydroxylase deficiency. | Tonetto-Fernandes, V., et al. 2006. J Clin Endocrinol Metab. 91: 2179-84. PMID: 16551734
- [21-deoxycortisol. A new marker of virilizing adrenal hyperplasia caused by 21-hydroxylase deficiency]. | Fiet, J., et al. 1989. Presse Med. 18: 1965-9. PMID: 2531882
- Cell foundry with high product specificity and catalytic activity for 21-deoxycortisol biotransformation. | Xiong, S., et al. 2017. Microb Cell Fact. 16: 105. PMID: 28610588
- Adrenal C11-oxy C21 steroids contribute to the C11-oxy C19 steroid pool via the backdoor pathway in the biosynthesis and metabolism of 21-deoxycortisol and 21-deoxycortisone. | Barnard, L., et al. 2017. J Steroid Biochem Mol Biol. 174: 86-95. PMID: 28774496
- A Liquid Chromatography/Tandem Mass Spectometry Profile of 16 Serum Steroids, Including 21-Deoxycortisol and 21-Deoxycorticosterone, for Management of Congenital Adrenal Hyperplasia. | Fiet, J., et al. 2017. J Endocr Soc. 1: 186-201. PMID: 29264476
- Radioimmunoassay for 21-deoxycortisol: clinical applications. | Gueux, B., et al. 1985. Acta Endocrinol (Copenh). 108: 537-44. PMID: 2986404
- Congenital Adrenal Hyperplasia: Time to Replace 17OHP with 21-Deoxycortisol. | Miller, WL. 2019. Horm Res Paediatr. 91: 416-420. PMID: 31450227
- Prenatal diagnosis of 21-hydroxylase deficiency congenital adrenal hyperplasia by simultaneous radioimmunoassay of 21-deoxycortisol and 17-hydroxyprogesterone in amniotic fluid. | Gueux, B., et al. 1988. J Clin Endocrinol Metab. 66: 534-7. PMID: 3258316
- Reassessment of predictive values of ACTH-stimulated serum 21-deoxycortisol and 17-hydroxyprogesterone to identify CYP21A2 heterozygote carriers and nonclassic subjects. | Costa-Barbosa, FA., et al. 2021. Clin Endocrinol (Oxf). 95: 677-685. PMID: 34231242
- Plasma acyl-carnitines, bilirubin, tyramine and tetrahydro-21-deoxycortisol in Parkinson's disease and essential tremor. A case control biomarker study. | Albillos, SM., et al. 2021. Parkinsonism Relat Disord. 91: 167-172. PMID: 34649109
- 21-Deoxycortisol is a Key Screening Marker for 21-Hydroxylase Deficiency. | Held, PK., et al. 2022. J Pediatr. 242: 213-219.e1. PMID: 34780778
- Electroacupuncture May Inhibit Oxidative Stress of Premature Ovarian Failure Mice by Regulating Intestinal Microbiota. | Geng, Z., et al. 2022. Oxid Med Cell Longev. 2022: 4362317. PMID: 36082082
- Evaluation of 21-deoxycortisol as a marker for the detection of heterozygous carriers of 21-hydroxylase deficiency. | Milewicz, A., et al. 1993. Endokrynol Pol. 44: 187-93. PMID: 8055790
- The application of a new highly-sensitive radioimmunoassay for plasma 21-deoxycortisol to the detection of steroid-21-hydroxylase deficiency. | Fiet, J., et al. 1994. Ann Clin Biochem. 31 (Pt 1): 56-64. PMID: 8154853
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
21-Deoxycortisol, 25 mg | sc-231273 | 25 mg | $330.00 |