Date published: 2026-8-24

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20β-Dihydroprogesterone (CAS 145-15-3)

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Alternate Names:
(20R)-20-Hydroxy-pregn-4-en-3-one
CAS Number:
145-15-3
Molecular Weight:
316.48
Molecular Formula:
C21H32O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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20β-Dihydroprogesterone, also known as allopregnanolone, is a neurosteroid and a derivative of progesterone. It is a naturally occurring hormone in the body and acts as a potent positive allosteric modulator of the GABA-A receptor. Allopregnanolone has neuroactive and neuroprotective properties and is involved in various physiological processes, including the regulation of mood, stress response, and cognitive function.


20β-Dihydroprogesterone (CAS 145-15-3) References

  1. Seasonal variations in sex steroids and male sexual characteristics in Scyliorhinus canicula.  |  Garnier, DH., et al. 1999. Gen Comp Endocrinol. 116: 281-90. PMID: 10562458
  2. Fundulus heteroclitus gonadotropins.5: Small scale chromatographic fractionation of pituitary extracts into components with different steroidogenic activities using homologous bioassays.  |  Lin, YW., et al. 2004. Reprod Biol Endocrinol. 2: 14. PMID: 15040801
  3. Glucocorticoid metabolism and Na+ transport in chicken intestine.  |  Mazancová, K., et al. 2005. J Exp Zool A Comp Exp Biol. 303: 113-22. PMID: 15662663
  4. Synthesis and regulation of 17α-hydroxy-20β-dihydroprogesterone in immature males of Oncorhynchus mykiss.  |  Vizziano, D., et al. 1995. Fish Physiol Biochem. 14: 289-99. PMID: 24197497
  5. Regulation of oocyte maturation in the rainbow trout,Salmo gairdneri: role of cyclic AMP in the mechanism of action of the maturation inducing steroid (MIS), 17α-hydroxy, 20β-dihydroprogesterone.  |  Jalabert, B. and Finet, B. 1986. Fish Physiol Biochem. 2: 65-74. PMID: 24233168
  6. Progestogen profiling in plasma during the estrous cycle in cattle using an LC-MS based approach.  |  Hankele, AK., et al. 2020. Theriogenology. 142: 376-383. PMID: 31708192
  7. Seasonal changes in the production of two novel and abundant ovarian steroids in the channel catfish (Ictalurus punctatus).  |  Ponthier, JL., et al. 1998. Gen Comp Endocrinol. 111: 141-55. PMID: 9679086

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

20β-Dihydroprogesterone, 10 mg

sc-498875
10 mg
$359.00

20β-Dihydroprogesterone, 100 mg

sc-498875A
100 mg
$2502.00