Molecular structure of 20-OH-LTB4, CAS Number: 79516-82-8
20-OH-LTB4 (CAS 79516-82-8)
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Alternate Names:
20-Hydroxy-LTB4; 20-Hydroxy-leukotriene B4
Application:
20-OH-LTB4 is a chemotactic agent for polymorphonuclear leukocytes
CAS Number:
79516-82-8
Purity:
≥99%
Molecular Weight:
352.5
Molecular Formula:
C20H32O5
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
20-OH-LTB4, or 20-hydroxy leukotriene B4, is a metabolite of leukotriene B4 (LTB4), which itself is a potent lipid mediator derived from arachidonic acid through the 5-lipoxygenase pathway. In research, 20-OH-LTB4 is studied for its involvement in the inflammatory response and immune regulation. Unlike its precursor LTB4, which is a strong chemotactic agent and activator of leukocytes, 20-OH-LTB4 has reduced biological activity and serves as an example of how leukotriene metabolism can regulate the intensity and duration of inflammation. Researchers utilize 20-OH-LTB4 to understand the metabolic pathways that control the biosynthesis and inactivation of leukotrienes, as well as to delineate the specific roles of different leukotriene metabolites in inflammation and immune responses.
20-OH-LTB4 (CAS 79516-82-8) References
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- Formation of 20-oxoleukotriene B4 by an alcohol dehydrogenase isolated from human neutrophils. | Gotoh, Y., et al. 1990. Biochim Biophys Acta. 1043: 52-6. PMID: 2155662
- Metabolomic profiling of regulatory lipid mediators in sputum from adult cystic fibrosis patients. | Yang, J., et al. 2012. Free Radic Biol Med. 53: 160-71. PMID: 22580336
- Leukotriene B₄ Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the ω-Oxidation of Leukotriene B₄ In Vitro and In Cellulo. | Archambault, AS., et al. 2017. PLoS One. 12: e0169804. PMID: 28068410
- The identification and formation of 20-aldehyde leukotriene B4. | Soberman, RJ., et al. 1988. J Biol Chem. 263: 7996-8002. PMID: 2836406
- NAD+-dependent conversion of 20-OH-LTB4 to 20-COOH-LTB4 by a cell-free system of human polymorphonuclear leukocytes. | Sumimoto, H., et al. 1985. Biochem Biophys Res Commun. 132: 864-70. PMID: 3000366
- Effect of structural modification at carbon atom 1 of leukotriene B4 on the chemotactic and metabolic response of human neutrophils. | Clancy, RM., et al. 1987. Anal Biochem. 161: 550-8. PMID: 3034102
- A comparative study on the release of leukotrienes and histamine by guinea pig lung and trachea after challenge with antigen or stimulation with ionophore A23187 or melittin. | Salari, H. 1987. Clin Exp Immunol. 67: 211-9. PMID: 3040307
- Characterization of human neutrophil leukotriene B4 omega-hydroxylase as a system involving a unique cytochrome P-450 and NADPH-cytochrome P-450 reductase. | Sumimoto, J., et al. 1988. Eur J Biochem. 172: 315-24. PMID: 3127205
- Activation of the human neutrophil secretory process with 5(S),12(R)-dihydroxy-6,14-cis-8,10-trans-eicosatetraenoic acid. | Smith, RJ., et al. 1984. Inflammation. 8: 365-84. PMID: 6097546
- Human monocytes respond to leukotriene B4 with a transient increase in cytosolic calcium. | Rediske, J., et al. 1993. Cell Immunol. 147: 438-45. PMID: 8384085
- Metabolism of gammalinolenic acid in human neutrophils. | Chilton-Lopez, ., et al. 1996. J Immunol. 156: 2941-7. PMID: 8609415
- Electrospray-collision-induced dissociation mass spectrometry of mono-, di- and tri-hydroxylated lipoxygenase products, including leukotrienes of the B-series and lipoxins. | Griffiths, WJ., et al. 1996. Rapid Commun Mass Spectrom. 10: 183-96. PMID: 8616266
- Role of human CYP4F2 in hepatic catabolism of the proinflammatory agent leukotriene B4. | Jin, R., et al. 1998. Arch Biochem Biophys. 359: 89-98. PMID: 9799565
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
20-OH-LTB4, 50 µg | sc-200959 | 50 µg | $623.00 | |||
20-OH-LTB4, 1 mg | sc-200959A | 1 mg | $6132.00 |