20-HETE Ethanolamide
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20-HETE Ethanolamide is a derivative of 20-HETE (20-hydroxyeicosatetraenoic acid), an important hydroxy fatty acid produced by the cytochrome P450 oxidation of arachidonic acid. This compound is part of a unique class of lipid mediators that have been the focus of various research studies due to their involvement in regulating numerous physiological processes. 20-HETE Ethanolamide specifically integrates the bioactive properties of 20-HETE with the ethanolamide group, which is thought to alter its interaction with cellular systems, potentially affecting its solubility, receptor binding, and overall bioactivity. In research environments, this compound has been used to study its effects on various signaling pathways that influence vascular tone, electrolyte balance, and cellular growth mechanisms. By understanding the actions of 20-HETE Ethanolamide, researchers can explore the complex dynamics of lipid signaling mediators in cellular environments. This includes examining how such compounds can influence intracellular calcium levels, modulate the function of various ion channels, and impact the expression of genes involved in cellular response mechanisms.
20-HETE Ethanolamide References
- The fatty acid amide hydrolase (FAAH). | Deutsch, DG., et al. 2002. Prostaglandins Leukot Essent Fatty Acids. 66: 201-10. PMID: 12052036
- Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides. | Kozak, KR., et al. 2002. J Biol Chem. 277: 44877-85. PMID: 12244105
- The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications. | Lambert, DM. and Fowler, CJ. 2005. J Med Chem. 48: 5059-87. PMID: 16078824
- Expression and purification of orphan cytochrome P450 4X1 and oxidation of anandamide. | Stark, K., et al. 2008. FEBS J. 275: 3706-17. PMID: 18549450
- The endocannabinoid anandamide is a substrate for the human polymorphic cytochrome P450 2D6. | Snider, NT., et al. 2008. J Pharmacol Exp Ther. 327: 538-45. PMID: 18698000
- Endocannabinoids anandamide and 2-arachidonoylglycerol are substrates for human CYP2J2 epoxygenase. | McDougle, DR., et al. 2014. J Pharmacol Exp Ther. 351: 616-27. PMID: 25277139
- Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism. | Tracy, TS., et al. 2016. Drug Metab Dispos. 44: 343-51. PMID: 26681736
- Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis. | Szabady, RL., et al. 2018. J Clin Invest. 128: 4044-4056. PMID: 30102254
- Antifungal Substances Produced by Xenorhabdus bovienii and Its Inhibition Mechanism against Fusarium solani. | Wang, Y., et al. 2022. Int J Mol Sci. 23: PMID: 36012310
- Anandamide, an endogenous cannabimimetic eicosanoid, binds to the cloned human cannabinoid receptor and stimulates receptor-mediated signal transduction. | Felder, CC., et al. 1993. Proc Natl Acad Sci U S A. 90: 7656-60. PMID: 8395053
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
20-HETE Ethanolamide, 25 µg | sc-220838 | 25 µg | $240.00 | |||
20-HETE Ethanolamide, 50 µg | sc-220838A | 50 µg | $465.00 |