Molecular structure of 20-HETE, CAS Number: 79551-86-3
20-HETE (CAS 79551-86-3)
Alternate Names:
20-hydroxy Arachidonic Acid
CAS Number:
79551-86-3
Molecular Weight:
320.50
Molecular Formula:
C20H32O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
20-HETE is a cytochrome P450 (CYP450) metabolite postulated to play an autacoid role in the cerebral and renal vasculature. In rat cerebral microvessels, this compound is a vasoconstrictor that mediates pressure-induced autoregulatory vasoconstriction. It is excreted mainly as the glucuronide conjugate where the concentration of free 20-HETE (20-40 pg/ml in human urine) is about 10-fold lower than the corresponding concentration of the 20-glucuronide. 20-HETE can be further metabolized by cyclooxygenase to 20-hydroxy PGG2 and 20-hydroxy PGH2.
20-HETE (CAS 79551-86-3) References
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- Production of 20-HETE and its role in autoregulation of cerebral blood flow. | Gebremedhin, D., et al. 2000. Circ Res. 87: 60-5. PMID: 10884373
- 20-hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells. | Kaduce, TL., et al. 2004. J Biol Chem. 279: 2648-56. PMID: 14612451
- 20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors alpha and gamma. | Fang, X., et al. 2007. Prostaglandins Other Lipid Mediat. 82: 175-84. PMID: 17164145
- Inhibitors of 20-hydroxyeicosatetraenoic acid (20-HETE) formation attenuate the natriuretic effect of dopamine. | Fernandez, MM., et al. 2012. Eur J Pharmacol. 686: 97-103. PMID: 22575524
- 20-Hydroxyeicosatetraenoic acid involved in endothelial activation and thrombosis. | Wang, J., et al. 2015. Am J Physiol Heart Circ Physiol. 308: H1359-67. PMID: 25820395
- Identification of novel CYP4F2 genetic variants exhibiting decreased catalytic activity in the conversion of arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE). | Kim, WY., et al. 2018. Prostaglandins Leukot Essent Fatty Acids. 131: 6-13. PMID: 29628049
- 20-HETE: Hypertension and Beyond. | Roman, RJ. and Fan, F. 2018. Hypertension. 72: 12-18. PMID: 29760152
- Detrimental Effects of Testosterone Addition to Estrogen Therapy Involve Cytochrome P-450-Induced 20-HETE Synthesis in Aorta of Ovariectomized Spontaneously Hypertensive Rat (SHR), a Model of Postmenopausal Hypertension. | Costa, TJ., et al. 2018. Front Physiol. 9: 490. PMID: 29867542
- Conflicting roles of 20-HETE in hypertension and renal end organ damage. | Zhang, C., et al. 2018. Eur J Pharmacol. 833: 190-200. PMID: 29886242
- The contribution of TRPV1 channel to 20-HETE-Aggravated ischemic neuronal injury. | Zhang, X., et al. 2018. Prostaglandins Other Lipid Mediat. 137: 63-68. PMID: 30041768
- 20-HETE in the regulation of vascular and cardiac function. | Rocic, P. and Schwartzman, ML. 2018. Pharmacol Ther. 192: 74-87. PMID: 30048707
- 20-HETE Inhibition by HET0016 Decreases the Blood-Brain Barrier Permeability and Brain Edema After Traumatic Brain Injury. | Lu, L., et al. 2018. Front Aging Neurosci. 10: 207. PMID: 30061822
- Inhibition of 20-hydroxyeicosatetraenoic acid (20-HETE) glucuronidation by non-steroidal anti-inflammatory drugs in human liver microsomes and recombinant UDP-glucuronosyltransferase enzymes. | Jarrar, YB., et al. 2020. Prostaglandins Leukot Essent Fatty Acids. 153: 102055. PMID: 31999978
- 20-hydroxyeicosatetraenoic acid (20-HETE) is a pivotal endogenous ligand for TRPV1-mediated neurogenic inflammation in the skin. | Hamers, A., et al. 2022. Br J Pharmacol. 179: 1450-1469. PMID: 34755897
- Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. | Kawamura, M., et al. 2022. J Med Chem. 65: 14599-14613. PMID: 36318660
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
20-HETE, 25 µg | sc-205102 | 25 µg | $260.00 | |||
20-HETE, 50 µg | sc-205102A | 50 µg | $485.00 | |||
20-HETE, 500 µg | sc-205102B | 500 µg | $3827.00 | |||
20-HETE, 2 mg | sc-205102C | 2 mg | $11455.00 | |||
20-HETE, 5 mg | sc-205102D | 5 mg | $21848.00 |