Molecular structure of 20-ethyl Prostaglandin F2α, CAS Number: 36950-85-3
20-ethyl Prostaglandin F2α (CAS 36950-85-3)
Application:
20-ethyl Prostaglandin F2α is an analog of PGF2α
CAS Number:
36950-85-3
Molecular Weight:
382.5
Molecular Formula:
C22H38O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
20-ethyl Prostaglandin F2α (20-ethyl PGF2α) is an analog of PGF2α in which the ω-chain has been extended by the addition of two more methylene carbon atoms.1 Unoprostone also contains lower side chain modifications (13,14-dihydro-15-keto) which severely limit its affinity for FP receptors, contributing to its lack of potency as a medication. 20-ethyl PGF2α retains the natural 15(S) allylic hydroxyl in the lower side chain, which may improve its potency as an intraocular hypotensive agent compared to unoprostone. In vivo effects may be prolonged using 20-ethyl PGF2α, as the activity of 15-hydroxy PGDH using 20-ethyl PGF2α as a substrate is only 35% of the activity observed with PGF2α.3,2
20-ethyl Prostaglandin F2α (CAS 36950-85-3) References
- Interactions between prostaglandin analogues and a receptor in bovine Corpora lutea. Correlation of dissociation constants with luteolytic potencies in hamsters. | Powell, WS., et al. 1975. Eur J Biochem. 59: 271-6. PMID: 1204612
- Studies on 15-hydroxyprostaglandin dehydrogenase from monkey lung. | Sun, FF., et al. 1976. Adv Prostaglandin Thromboxane Res. 1: 163-9. PMID: 826140
- Unoprostone (isopropyl unoprostone). | Haria, M. and Spencer, CM. 1996. Drugs Aging. 9: 213-8; discussion 219-20. PMID: 8877315
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
20-ethyl Prostaglandin F2α, 1 mg | sc-205100 | 1 mg | $60.00 | |||
20-ethyl Prostaglandin F2α, 5 mg | sc-205100A | 5 mg | $272.00 |