20-carboxy Arachidonic Acid (CAS 79551-84-1)
QUICK LINKS
20-carboxy Arachidonic Acid, listed under CAS number 79551-84-1, is a derivative of arachidonic acid, where an additional carboxyl group has been introduced at the omega end of the molecule. This modification significantly alters the chemical and biological properties of the original fatty acid. In research, 20-carboxy Arachidonic Acid is particularly valuable for studying lipid oxidation processes and the role of oxidized fatty acids in cellular signaling pathways. The presence of the extra carboxyl group enhances the molecule′s polarity and potentially increases its reactivity, making it a subject of interest in studies related to the interaction of fatty acids with cellular receptors and enzymes. Researchers employ this compound to explore how the structural changes in fatty acids affect their function within cell membranes, particularly how such modifications influence the interaction with proteins involved in inflammatory signaling pathways. By understanding these interactions, researchers can gain insights into the fundamental mechanisms of cell signaling and regulation, which are crucial for broad biological processes.
20-carboxy Arachidonic Acid (CAS 79551-84-1) References
- 16(R)-hydroxy-5,8,11,14-eicosatetraenoic acid, a new arachidonate metabolite in human polymorphonuclear leukocytes. | Bednar, MM., et al. 2000. Biochem Pharmacol. 60: 447-55. PMID: 10856441
- 20-hydroxyeicosatetraenoic acid (20-HETE) metabolism in coronary endothelial cells. | Kaduce, TL., et al. 2004. J Biol Chem. 279: 2648-56. PMID: 14612451
- 20-carboxy-arachidonic acid is a dual activator of peroxisome proliferator-activated receptors alpha and gamma. | Fang, X., et al. 2007. Prostaglandins Other Lipid Mediat. 82: 175-84. PMID: 17164145
- Degradation of very long chain dicarboxylic polyunsaturated fatty acids in mouse hepatocytes, a peroxisomal process. | Nguyen, SD., et al. 2008. Biochim Biophys Acta. 1781: 400-5. PMID: 18619556
- 20-HETE and blood pressure regulation: clinical implications. | Wu, CC., et al. 2014. Cardiol Rev. 22: 1-12. PMID: 23584425
- Polyunsaturated fatty acid metabolites as novel lipidomic biomarkers for noninvasive diagnosis of nonalcoholic steatohepatitis. | Loomba, R., et al. 2015. J Lipid Res. 56: 185-92. PMID: 25404585
- Ethanol at low concentrations protects glomerular podocytes through alcohol dehydrogenase and 20-HETE. | McCarthy, ET., et al. 2015. Prostaglandins Other Lipid Mediat. 116-117: 88-98. PMID: 25447342
- Cytochrome P450 ω-Hydroxylases in Inflammation and Cancer. | Johnson, AL., et al. 2015. Adv Pharmacol. 74: 223-62. PMID: 26233909
- The role of 20-HETE in cardiovascular diseases and its risk factors. | Waldman, M., et al. 2016. Prostaglandins Other Lipid Mediat. 125: 108-17. PMID: 27287720
- Arachidonic Acid Metabolite as a Novel Therapeutic Target in Breast Cancer Metastasis. | Borin, TF., et al. 2017. Int J Mol Sci. 18: PMID: 29292756
- Arachidonic Acid Metabolism and Kidney Inflammation. | Wang, T., et al. 2019. Int J Mol Sci. 20: PMID: 31357612
- Eicosanoid Profiles in the Vitreous Humor of Patients with Proliferative Diabetic Retinopathy. | Lin, AL., et al. 2020. Int J Mol Sci. 21: PMID: 33050335
- Targeted fatty acid metabolomics to discover Parkinson's disease associated metabolic alteration. | Zhang, J., et al. 2021. J Mass Spectrom. 56: e4781. PMID: 34523199
- Altered renal P-450 metabolism of arachidonic acid in Dahl salt-sensitive rats. | Ma, YH., et al. 1994. Am J Physiol. 267: R579-89. PMID: 8067471
- The role of the cytochrome P450-dependent metabolites of arachidonic acid in blood pressure regulation and renal function: a review. | Rahman, M., et al. 1997. Am J Hypertens. 10: 356-65. PMID: 9056695
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
20-carboxy Arachidonic Acid, 25 µg | sc-220837 | 25 µg | $240.00 | |||
20-carboxy Arachidonic Acid, 50 µg | sc-220837A | 50 µg | $349.00 |