2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate (CAS 1001067-09-9)

2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate (TMS-NT) has emerged as a notable silylating agent. This novel compound has proven itself as a stable, non-toxic, and non-volatile reagent, making it exceptionally well-suited for an array of laboratory experiments. 2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate finds extensive utility in scientific research. Notably, it serves as an efficient silylating agent for safeguarding alcohols and amines, as well as for synthesizing various silyl ethers. Moreover, it plays a pivotal role in peptide synthesis, providing protection for the carboxyl group of amino acids. Additionally, 2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate acts as a valuable reagent in the synthesis of diverse heterocyclic compounds, including thiazoles, oxazoles, and pyrazoles. The mechanism of action of 2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate stems from its ability to engage nucleophilic groups, such as alcohols, amines, and carboxyl groups. The reaction proceeds through nucleophilic substitution, whereby the chloride ion of TMSCl is replaced by the nucleophilic group. The resultant product is 2-(Trimethylsilyl)ethyl 3-Nitro-1H-1,2,4-triazole-1-carboxylate, a stable and non-volatile reagent of immense value.