Molecular structure of 2-Trifluoromethylindole, CAS Number: 51310-54-4
2-Trifluoromethylindole (CAS 51310-54-4)
CAS Number:
51310-54-4
Purity:
≥96%
Molecular Weight:
185.15
Molecular Formula:
C9H6F3N
Supplemental Information:
This is as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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2-Trifluoromethylindole, a heterocyclic compound featuring a trifluoromethyl group connected to the indole ring, serves as a prominent cornerstone in organic synthesis. The scientific research applications of 2-Trifluoromethylindole are diverse. It has found utility as an intermediate in synthesizing agrochemicals, fluorescent probes, and imaging agents. Moreover, it has played a vital role in investigating enzyme-catalyzed reactions and protein-ligand interactions.The compound has exhibited various modes of interaction with proteins and enzymes. It can bind through hydrogen bonding, hydrophobic interactions, and electrostatic interactions.
2-Trifluoromethylindole (CAS 51310-54-4) References
- Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083). | Zhou, HJ., et al. 2015. J Med Chem. 58: 9480-97. PMID: 26565666
- Electrophilic trifluoromethylation of carbonyl compounds and their nitrogen derivatives under copper catalysis. | Prieto, A., et al. 2016. Chem Commun (Camb). 52: 869-81. PMID: 26571150
- Synthesis and biological evaluation of isomeric methoxy substitutions on anti-cancer indolyl-pyridinyl-propenones: Effects on potency and mode of activity. | Trabbic, CJ., et al. 2016. Eur J Med Chem. 122: 79-91. PMID: 27343855
- Synthesis and Reactions of 3-Halogenated 2-CF3-Indoles. | Muzalevskiy, VM., et al. 2022. Molecules. 27: PMID: 36557954
- Novel indole-ring formation by thermolysis of 2-(N-acylamino)-benzylphosphonium salts. Effective synthesis of 2-trifluoromethylindoles | Kazuyuki Miyashita, Katsunori Kondoh, Katsutoshi Tsuchiya, Hideto Miyabe and Takeshi Imanishi. 1996,. J. Chem. Soc., Perkin Trans. 1,: 1261-1268.
- Recent developments in indole ring synthesis-methodology and applications | . 2000,. J. Chem. Soc., Perkin Trans. 1,: 1045-1075.
- Synthesis of 2-trifluoromethyl indoles via visible-light induced intramolecular radical cyclization† | Xichang Dong, Yumin Hu, Tiebo Xiao and Lei Zhou*. 2015,. (Communication) RSC Adv.,. 5,: 39625-39629.
- Fischer Reaction with 2-Perfluoroalkylated Cyclic Imines ― An Efficient Route to 2-Perfluoroalkyl-Substituted Tryptamines and Their Derivatives and Homologues | , et al. September 2015. European Journal of Organic Chemistry. Volume2015, Issue29: Pages 6479-6488.
- Palladium-catalyzed cyclization reaction of N-(2-Haloaryl)alkynylimines: Synthesis of 3-acylindoles using water as the sole solvent and oxygen source | and An-An Zhang, Tuanjie Meng, Wenli Wang, Xueli Liu, Yupei Zhu, Lantao Liu. April 2020. Applied Organometallic Chemistry. Volume34, Issue4: e5513.
- Pd-catalyzed coupling of arylamines and 2-bromo-3,3,3-trifluoropropene | T Kino, Y Nagase, Y Horino, T Yamakawa - Journal of Molecular Catalysis A …, 2008 - Elsevier. 3 March 2008,. Elsevier Journal of Molecular Catalysis A: Chemical. Volume 282, Issues 1–2,: Pages 34-51.
- Copper catalysed domino decarboxylative cross coupling-cyclisation reactions: synthesis of 2-arylindoles | T Ponpandian, S Muthusubramanian - Tetrahedron Letters, 2012 - Elsevier. 8 8 August 2012, 2012,. Tetrahedron Letters. Volume 53, Issue 32,: Pages 4248-4252.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Trifluoromethylindole, 500 mg | sc-275191 | 500 mg | $97.00 | |||
2-Trifluoromethylindole, 1 g | sc-275191A | 1 g | $188.00 |