Date published: 2026-3-7

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2-Trifluoromethyl-2-propanol (CAS 507-52-8)

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Alternate Names:
2-(Trifluoromethyl)propan-2-ol
CAS Number:
507-52-8
Molecular Weight:
128.09
Molecular Formula:
C4H7F3O
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Trifluoromethyl-2-propanol, known as 2-TFM, is a versatile chemical compound extensively utilized in organic synthesis and laboratory research. This colorless, volatile, and flammable liquid is classified as a fluorinated alcohol with a molecular formula of C3H7F3O and a molecular weight of 134.09 g/mol. Its broad range of applications encompasses the pharmaceutical, agrochemical, and various other industries. 2-Trifluoromethyl-2-propanol serves as a valuable solvent, an intermediate in organic synthesis, and a reactant in diverse chemical reactions.


2-Trifluoromethyl-2-propanol (CAS 507-52-8) References

  1. Calpha-H bond-stretching frequency in alcohols as a probe of hydrogen-bonding strength: a combined vibrational spectroscopic and theoretical study of n-[1-D]propanol.  |  Jarmelo, S., et al. 2005. J Phys Chem A. 109: 2069-77. PMID: 16838977
  2. Clinical amyloid imaging in Alzheimer's disease.  |  Herholz, K. and Ebmeier, K. 2011. Lancet Neurol. 10: 667-70. PMID: 21683932
  3. Highly diastereo- and enantioselective CuH-catalyzed synthesis of 2,3-disubstituted indolines.  |  Ascic, E. and Buchwald, SL. 2015. J Am Chem Soc. 137: 4666-9. PMID: 25826004
  4. Light-Mediated Atom Transfer Radical Polymerization of Semi-Fluorinated (Meth)acrylates: Facile Access to Functional Materials.  |  Discekici, EH., et al. 2017. J Am Chem Soc. 139: 5939-5945. PMID: 28406296
  5. Organocatalyzed Photocontrolled Radical Polymerization of Semifluorinated (Meth)acrylates Driven by Visible Light.  |  Gong, H., et al. 2018. Angew Chem Int Ed Engl. 57: 333-337. PMID: 29135062
  6. Externally controlled atom transfer radical polymerization.  |  Pan, X., et al. 2018. Chem Soc Rev. 47: 5457-5490. PMID: 29868657
  7. Enhancing the efficiency of semiconducting quantum dot photocatalyzed atom transfer radical polymerization by ligand shell engineering.  |  Zhu, Y., et al. 2021. J Chem Phys. 154: 204903. PMID: 34241152

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Trifluoromethyl-2-propanol, 5 g

sc-225550
5 g
$56.00