Date published: 2026-4-28

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2-(Trifluoroacetyl)thiophene (CAS 651-70-7)

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Application:
2-(Trifluoroacetyl)thiophene is a CF3 acetate thiophene compound
CAS Number:
651-70-7
Purity:
≥95%
Molecular Weight:
180.15
Molecular Formula:
C6H3F3OS
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-(Trifluoroacetyl)thiophene (TFAT) is an organosulfur compound featuring a trifluoroacetyl group bonded to a thiophene ring. 2-(Trifluoroacetyl)thiophene serves as a pivotal intermediate in the production of diverse organic substances, encompassing agrochemicals. It functions as a reagent for generating an array of compounds and materials, making it a versatile foundational component for synthesizing a broad spectrum of molecules and substances. 2-(Trifluoroacetyl)thiophene plays a vital role in numerous scientific research applications, serving as a reagent in the creation of organic compounds. It also plays a pivotal role in crafting polymers, catalysts, and various other materials. 2-(Trifluoroacetyl)thiophene plays a significant role in the synthesis of organic semiconductors, electrochromic materials, and optical materials. In the realm of organic chemistry, 2-(Trifluoroacetyl)thiophene operates as a nucleophile, participating in reactions with electrophiles, such as halides and other organic compounds, to yield novel compounds through nucleophilic substitution. 2-(Trifluoroacetyl)thiophene can act as a leaving group in organic chemistry, facilitating its replacement by alternative compounds.


2-(Trifluoroacetyl)thiophene (CAS 651-70-7) References

  1. Cloning and overexpression of the Exiguobacterium sp. F42 gene encoding a new short chain dehydrogenase, which catalyzes the stereoselective reduction of ethyl 3-oxo-3-(2-thienyl)propanoate to ethyl (S)-3-hydroxy-3-(2-thienyl)propanoate.  |  Wada, M., et al. 2004. Biosci Biotechnol Biochem. 68: 1481-8. PMID: 15277752
  2. Classification structure-activity relationship (CSAR) studies for prediction of genotoxicity of thiophene derivatives.  |  Du, H., et al. 2008. Toxicol Lett. 177: 10-9. PMID: 18243595
  3. 3D QSAR of aminophenyl benzamide derivatives as histone deacetylase inhibitors.  |  Mahipal,., et al. 2010. Med Chem. 6: 277-85. PMID: 20977417
  4. Synthesis of pentafluorinated β-hydroxy ketones.  |  Zhang, P. and Wolf, C. 2012. J Org Chem. 77: 8840-4. PMID: 22992005
  5. Precursor-directed combinatorial biosynthesis of cephalosporin analogue by endolithic actinobacterium Streptomyces sp. AL51 by utilizing thiophene derivative.  |  Bhattacharjee, K., et al. 2018. 3 Biotech. 8: 31. PMID: 29291144
  6. Reaction of indoles with aromatic fluoromethyl ketones: an efficient synthesis of trifluoromethyl(indolyl)phenylmethanols using K2CO3/n-Bu4PBr in water.  |  Pillaiyar, T., et al. 2020. Beilstein J Org Chem. 16: 778-790. PMID: 32395181
  7. Purification and characterization of fluorinated ketone reductase from Geotrichum candidum NBRC 5767  |  Cao, C., Fukae, T., Yamamoto, T., Kanamaru, S., & Matsuda, T. 2013. Biochemical engineering journal. 76: 13-16.
  8. 2-(Trifluoroacetyl) thiophene as an electrolyte additive for high-voltage lithium-ion batteries using LiCoO2 cathode.  |  Sun, Y., Huang, J., Xiang, H., Liang, X., Feng, Y., & Yu, Y. 2020. Journal of Materials Science & Technology. 55: 198-202.

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-(Trifluoroacetyl)thiophene, 1 g

sc-223275
1 g
$34.00

2-(Trifluoroacetyl)thiophene, 5 g

sc-223275A
5 g
$117.00