Molecular structure of 2-Pyrrolidinone, CAS Number: 616-45-5
2-Pyrrolidinone (CAS 616-45-5)
CAS Number:
616-45-5
Purity:
≥99%
Molecular Weight:
85.10
Molecular Formula:
C4H7NO
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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2-Pyrrolidinone, classified as an organic compound and a member of heterocyclic compounds, exhibits a cyclic structure composed of five carbon atoms and one nitrogen atom. This versatile compound holds a wide range of applications in both scientific and industrial domains. It acts as a fundamental raw material in the production of polymers, surfactants, and diverse chemicals. 2-Pyrrolidinone operates through multiple mechanisms of action, further enhancing its significance. As a nucleophile, it actively reacts with electrophiles like alkenes and aromatic compounds. In the capacity of a reducing agent, pyrrolidone effectively reduces aldehydes and ketones. Furthermore, it functions as a catalyst, efficiently promoting the formation of fresh bonds between atoms or molecules.
2-Pyrrolidinone (CAS 616-45-5) References
- The aniracetam metabolite 2-pyrrolidinone induces a long-term enhancement in AMPA receptor responses via a CaMKII pathway. | Nishizaki, T. and Matsumura, T. 2002. Brain Res Mol Brain Res. 98: 130-4. PMID: 11834304
- 2-pyrrolidinone moiety is not critical for the cognition-enhancing activity of piracetam-like drugs. | Scapecchi, S., et al. 2003. Farmaco. 58: 715-22. PMID: 13679165
- 2-pyrrolidinone induces a long-lasting facilitation of hippocampal synaptic transmission by enhancing alpha7 ACh receptor responses via a PKC pathway. | Miyamoto, H., et al. 2003. Brain Res Mol Brain Res. 117: 91-6. PMID: 14499485
- Percutaneous absorption of co-administered N-methyl-2-[14C]pyrrolidinone and 2-[14C]pyrrolidinone in the rat. | Midgley, I., et al. 1992. Food Chem Toxicol. 30: 57-64. PMID: 1544607
- Validated hydrophilic interaction LC-MS/MS method for determination of 2-pyrrolidinone residue: applied to a depletion study of 2-pyrrolidinone in swine liver. | Liu, Y., et al. 2011. Anal Bioanal Chem. 399: 1371-80. PMID: 21116620
- rac-Methyl (3aR*,4S*,5R*,7aR*)-5,7a-bis-(acet-yloxy)-3-oxo-2-phenyl-octa-hydro-1H-iso-indole-4-carboxyl-ate. | Toze, FA., et al. 2013. Acta Crystallogr Sect E Struct Rep Online. 69: o1555. PMID: 24098237
- 2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis. | Kennedy, AD., et al. 2019. Front Neurosci. 13: 394. PMID: 31133775
- One-Pot Enantioselective Synthesis of 2-Pyrrolidinone Derivatives Bearing a Trifluoromethylated All-Carbon Quaternary Stereocenter. | Jia, Z., et al. 2019. Org Lett. 21: 9584-9588. PMID: 31746209
- Synthesis of novel 2-pyrrolidinone and pyrrolidine derivatives and study of their inhibitory activity against autotaxin enzyme. | Gerokonstantis, DT., et al. 2020. Bioorg Med Chem. 28: 115216. PMID: 31864778
- Efficient synthesis of tert-butyl 3-cyano-3-cyclopropyl-2-oxopyrrolidine-4-carboxylates: Highly functionalized 2-pyrrolidinone enabling access to novel macrocyclic Tyk2 inhibitors. | Sasaki, Y., et al. 2020. Bioorg Med Chem Lett. 30: 126963. PMID: 31980341
- Corrigendum: 2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis. | Kennedy, AD., et al. 2019. Front Neurosci. 13: 1344. PMID: 32082103
- 2-Pyrrolidinone in human cerebrospinal fluid: a major constituent of total gamma-aminobutyric acid. | Haegele, KD., et al. 1987. J Neurochem. 49: 1402-6. PMID: 3668531
- 2-Pyrrolidinone and succinimide endogenously present in several mammalian species. | Bandle, EF., et al. 1984. Life Sci. 35: 2205-12. PMID: 6503611
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2-Pyrrolidinone, 50 g | sc-238212 | 50 g | $52.00 |