Date published: 2026-5-9

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2-Pyridinesulfonyl Chloride (CAS 66715-65-9)

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CAS Number:
66715-65-9
Molecular Weight:
177.60
Molecular Formula:
C5H4ClNO2S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Pyridinesulfonyl Chloride is a highly acidic compound with a pKa value of 0.6, and it serves as a catalyst in organic synthesis. Its utility extends to the synthesis of biologically active compounds, including peptides, nucleosides, and related derivatives. Furthermore, it finds application in the production of dyes, pharmaceuticals, and agrochemicals. Additionally, it plays a role in the synthesis of polymers such as polystyrene and polyethylene, as well as in the formation of metal complexes.


2-Pyridinesulfonyl Chloride (CAS 66715-65-9) References

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  3. Utilization of molybdenum- and palladium-catayzed dynamic kinetic asymmetric transformations for the preparation of tertiary and quaternary stereogenic centers: a concise synthesis of tipranavir.  |  Trost, BM. and Andersen, NG. 2002. J Am Chem Soc. 124: 14320-1. PMID: 12452702
  4. Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors.  |  Yamashita, DS., et al. 2006. J Med Chem. 49: 1597-612. PMID: 16509577
  5. Efficient large-scale synthesis of BILN 2061, a potent HCV protease inhibitor, by a convergent approach based on ring-closing metathesis.  |  Yee, NK., et al. 2006. J Org Chem. 71: 7133-45. PMID: 16958506
  6. Synthesis and evaluation of a novel 2-azabicyclo[2.2.2]octane class of long chain fatty acid elongase 6 (ELOVL6) inhibitors.  |  Sasaki, T., et al. 2009. Bioorg Med Chem. 17: 5639-47. PMID: 19596583
  7. PyFluor: A Low-Cost, Stable, and Selective Deoxyfluorination Reagent.  |  Nielsen, MK., et al. 2015. J Am Chem Soc. 137: 9571-4. PMID: 26177230
  8. (18)F-Labeling of Arenes and Heteroarenes for Applications in Positron Emission Tomography.  |  Preshlock, S., et al. 2016. Chem Rev. 116: 719-66. PMID: 26751274
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  10. Substituted arylsulphonamides as inhibitors of perforin-mediated lysis.  |  Spicer, JA., et al. 2017. Eur J Med Chem. 137: 139-155. PMID: 28582670
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Pyridinesulfonyl Chloride, 250 mg

sc-476860
250 mg
$496.00

2-Pyridinesulfonyl Chloride, 1 g

sc-476860A
1 g
$713.00