Date published: 2026-3-6

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2-Picolinic acid (CAS 98-98-6)

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Alternate Names:
Pyridine-2-carboxylic acid
CAS Number:
98-98-6
Purity:
99%
Molecular Weight:
123.11
Molecular Formula:
C6H5NO2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Picolinic acid, also known as pyridine-3-carboxylic acid, is an organic compound extensively utilized in scientific and industrial fields. It is a white solid with a strong odor and demonstrates solubility in water and alcohol. It acts as a modulator of various biochemical pathways. These pathways include the generation of reactive oxygen species, the regulation of cell proliferation and death, as well as the control of gene expression. Additionally, picolinic acid exhibits interaction capabilities with an array of proteins, enzymes, and other molecules. The biochemical and physiological effects of picolinic acid, revealing its capacity to modulate reactive oxygen species production, regulate cell proliferation and death, and influence gene expression.


2-Picolinic acid (CAS 98-98-6) References

  1. Arylation of 2-substituted pyridines via Pd-catalyzed decarboxylative cross-coupling reactions of 2-picolinic acid.  |  Li, X., et al. 2013. Chem Commun (Camb). 49: 312-4. PMID: 23172107
  2. Synthesis, crystal structure, and thermal decomposition of the cobalt(II) complex with 2-picolinic acid.  |  Li, D. and Zhong, GQ. 2014. ScientificWorldJournal. 2014: 641608. PMID: 24578654
  3. Isolation of a 2-picolinic acid-assimilating bacterium and its proposed degradation pathway.  |  Zheng, C., et al. 2017. Bioresour Technol. 245: 681-688. PMID: 28917103
  4. One-step synthesis of Fe3PtPd(OH)2[Picolinic acid]8(H2O)4 hybrid nanorods: efficient and stable electrocatalyst for oxygen reduction reaction in alkaline solution.  |  Asiabi, H., et al. 2018. Sci Rep. 8: 15325. PMID: 30333559
  5. Metal-Free Decarboxylative Alkoxylation of 2-Picolinic Acid and Its Derivatives with Cyclic Ethers: One Step Construction of C-O and C-Cl Bonds.  |  Yu, X., et al. 2018. Org Lett. 20: 6780-6784. PMID: 30350643
  6. Synergistic Effect between Different Coordination Geometries of Lanthanides and Various Coordination Modes of 2-Picolinic Acid Ligands Tuning Three Types of Rare 3d-4f Heterometallic Tungstoantimonates.  |  Chen, Y., et al. 2018. Inorg Chem. 57: 15079-15092. PMID: 30480437
  7. Zhizhu decoction alleviates slow transit constipation by regulating aryl hydrocarbon receptor through gut microbiota.  |  Wen, Y., et al. 2023. Pharm Biol. 61: 111-124. PMID: 36562308
  8. Tryptophan and Substance Abuse: Mechanisms and Impact.  |  Davidson, M., et al. 2023. Int J Mol Sci. 24: PMID: 36769059
  9. Design, Synthesis, Herbicidal Activity, and Structure-Activity Relationship Study of Novel 6-(5-Aryl-Substituted-1-Pyrazolyl)-2-Picolinic Acid as Potential Herbicides.  |  Feng, T., et al. 2023. Molecules. 28: PMID: 36771096
  10. Cocrystal of phloretin with isoniazid: preparation, characterization, and evaluation.  |  Lu, Z., et al. 2023. RSC Adv. 13: 10914-10922. PMID: 37033443
  11. Lipopolysaccharide-induced changes in the kynurenine pathway and symptoms of sickness behavior in humans.  |  Balter, LJ., et al. 2023. Psychoneuroendocrinology. 153: 106110. PMID: 37075653
  12. Expression and Characterization of 3,6-Dihydroxy-picolinic Acid Decarboxylase PicC of Bordetella bronchiseptica RB50.  |  Yuan, C., et al. 2023. Microorganisms. 11: PMID: 37110277
  13. Tryptophan intake, not always the more the better.  |  Hu, D., et al. 2023. Front Nutr. 10: 1140054. PMID: 37113297
  14. Determination of Picolinic Acid by HPLC Coupled With Postcolumn Photo Irradiation Using Zinc Acetate as a Fluorescent Derivatization Reagent.  |  Mawatari, KI., et al. 2023. Int J Tryptophan Res. 16: 11786469221146596. PMID: 37151811

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Picolinic acid, 5 g

sc-238205
5 g
$24.00

2-Picolinic acid, 100 g

sc-238205A
100 g
$54.00

2-Picolinic acid, 1 kg

sc-238205B
1 kg
$345.00