Date published: 2026-4-30

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2-Phthalaldehyde (CAS 643-79-8)

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Alternate Names:
o-Phthalaldehyde; o-Phthalic dicarboxaldehyde; Benzene-1,2-dicarboxaldehyde
Application:
2-Phthalaldehyde is a compound used in precolumn derivatization of amino acids for HPLC separation
CAS Number:
643-79-8
Molecular Weight:
134.13
Molecular Formula:
C8H6O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Phthalaldehyde is a chemical compound that exhibits a strong affinity for primary amines, resulting in the formation of a highly fluorescent blue-colored product. This property makes it valuable for the rapid detection and visualization of histamine, as it produces a distinct yellow stain when reacting with this compound. 2-Phthalaldehyde is used in precolumn derivatization of amino acids for HPLC separation. 2-Phthalaldehyde is also used for flow cytometric measurements of protein thiol groups.


2-Phthalaldehyde (CAS 643-79-8) References

  1. Purification, molecular cloning, and catalytic activity of Schizosaccharomyces pombe pyridoxal reductase. A possible additional family in the aldo-keto reductase superfamily.  |  Nakano, M., et al. 1999. J Biol Chem. 274: 23185-90. PMID: 10438489
  2. Photochemistry of 2-alkoxymethyl-5-methylphenacyl chloride and benzoate.  |  Plístil, L., et al. 2006. J Org Chem. 71: 8050-8. PMID: 17025294
  3. Complete nucleotide sequence of cDNA and predicted amino acid sequence of rat acyl-CoA oxidase.  |  Miyazawa, S., et al. 1987. J Biol Chem. 262: 8131-7. PMID: 3036800
  4. Prostaglandin D2 and prostaglandin D synthetase in mast cell deficient mice.  |  Ikai, K., et al. 1984. Prostaglandins. 27: 877-85. PMID: 6435183
  5. Measurement of polyamine efflux from cells in culture.  |  Wallace, HM. and Mackarel, AJ. 1998. Methods Mol Biol. 79: 157-65. PMID: 9463831

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Phthalaldehyde, 1 g

sc-206483
1 g
$38.00

2-Phthalaldehyde, 5 g

sc-206483A
5 g
$68.00

2-Phthalaldehyde, 25 g

sc-206483B
25 g
$114.00

2-Phthalaldehyde, 100 g

sc-206483C
100 g
$198.00