Date published: 2026-4-30

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2-Phenylquinoline (CAS 612-96-4)

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CAS Number:
612-96-4
Molecular Weight:
205.25
Molecular Formula:
C15H11N
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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2-Phenylquinoline (2-PQ) is a member of the quinoline family, characterized by its aromatic heterocyclic structure. This compound holds significance in the realm of natural products and actively participates in a variety of biochemical and physiological processes. Scientific research extensively benefits from the applications of 2-Phenylquinoline. It has been utilized in the synthesis of numerous natural products, encompassing terpenes, alkaloids, and flavonoids. 2-Phenylquinoline is recognized for its interaction with enzymes, including cytochrome P450.


2-Phenylquinoline (CAS 612-96-4) References

  1. Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents.  |  Ko, TC., et al. 2001. Bioorg Med Chem Lett. 11: 279-82. PMID: 11212091
  2. Gastroprotective activity of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora Krause (Rutaceae).  |  Zanatta, F., et al. 2009. Chem Biol Interact. 180: 312-7. PMID: 19497430
  3. Evaluation of antinociceptive effects of Galipea longiflora alkaloid extract and major alkaloid 2-phenylquinoline.  |  Campos-Buzzi, F., et al. 2010. Methods Find Exp Clin Pharmacol. 32: 707-11. PMID: 21225005
  4. Descriptor analysis of estrogen receptor β-selective ligands using 2-phenylquinoline, tetrahydrofluorenone and 3-hydroxy 6H-benzo[c]chromen-6-one scaffolds.  |  Balaji, ., et al. 2011. J Enzyme Inhib Med Chem. 26: 831-42. PMID: 21438712
  5. Highly efficient electrochemiluminescence from iridium(III) complexes with 2-phenylquinoline ligand.  |  Zhou, Y., et al. 2015. Dalton Trans. 44: 1858-65. PMID: 25482203
  6. The 'racemic approach' in the evaluation of the enantiomeric NorA efflux pump inhibition activity of 2-phenylquinoline derivatives.  |  Carotti, A., et al. 2016. J Pharm Biomed Anal. 129: 182-189. PMID: 27429367
  7. Boosting Effect of 2-Phenylquinoline Efflux Inhibitors in Combination with Macrolides against Mycobacterium smegmatis and Mycobacterium avium.  |  Machado, D., et al. 2015. ACS Infect Dis. 1: 593-603. PMID: 27623057
  8. Gastroprotective and anti-secretory mechanisms of 2-phenylquinoline, an alkaloid isolated from Galipea longiflora.  |  Breviglieri, E., et al. 2017. Phytomedicine. 25: 61-70. PMID: 28190472
  9. Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli.  |  Machado, D., et al. 2017. PeerJ. 5: e3168. PMID: 28516003
  10. 2-Phenylquinoline S. aureus NorA Efflux Pump Inhibitors: Evaluation of the Importance of Methoxy Group Introduction.  |  Felicetti, T., et al. 2018. J Med Chem. 61: 7827-7848. PMID: 30067360
  11. Ir-Ho bimetallic complex-mediated low-dose radiotherapy/radiodynamic therapy in vivo.  |  Wang, C., et al. 2020. Chem Commun (Camb). 56: 6193-6196. PMID: 32432578
  12. Unsymmetric Heteroleptic Ir(III) Complexes with 2-Phenylquinoline and Coumarin-Based Ligand Isomers for Tuning Character of Triplet Excited States and Achieving High Electroluminescent Efficiencies.  |  Feng, Z., et al. 2020. Inorg Chem. 59: 12362-12374. PMID: 32799532
  13. Discrepancy between Proline and Homoproline in Chiral Recognition and Diastereomeric Photoreactivity with Iridium(III) Complexes.  |  Xiong, MF., et al. 2021. Inorg Chem. 60: 5423-5431. PMID: 33818063
  14. The interaction of substituted 2-phenylquinoline intercalators with poly(A).poly(U): classical and threading intercalation modes with RNA.  |  Zhao, M., et al. 1994. Biopolymers. 34: 61-73. PMID: 7509202

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

2-Phenylquinoline, 1 g

sc-230643
1 g
$47.00