2-Oxo-Zoniporide Hydrochloride (CAS 372078-42-7)

2-Oxo-Zoniporide Hydrochloride is a compound that has attracted attention in biochemical research due to its selectivity and activity in inhibiting sodium-hydrogen exchangers (NHE). This inhibition is of particular interest in studies related to cellular pH regulation, as NHE plays a pivotal role in controlling intracellular pH levels by exchanging intracellular hydrogen ions for extracellular sodium ions. 2-Oxo-Zoniporide Hydrochloride is used as a tool in investigating the physiological and pathological roles of NHE, including its involvement in cardiac function, where NHE activity can significantly impact myocardial cells during ischemic conditions. The compound′s effects on NHE are also relevant in research on other conditions where altered pH homeostasis is a factor, such as neurological disorders and certain metabolic diseases. Additionally, as a hydrochloride salt, 2-Oxo-Zoniporide Hydrochloride is soluble in aqueous solutions, which facilitates its application in various experimental setups.